Article (Scientific journals)
Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta 15
Dhaese, S.; Jonckheere, V.; Goethals, M. et al.
2007In FEBS Letters, 581 (25), p. 4809-4815
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Keywords :
thymosin; prostate; cancer; actin; cytoskeleton; cell migration
Abstract :
[en] A peptide with a sequence identical to rat thymosin beta(Tb)15 was reported to be upregulated in human prostate cancer. However, in this report we provide evidence that TbNB, initially identified in human neuroblastoma, is the only Tb isoform upregulated in human prostate cancer and that the Tb15 sequence is not present herein. In addition, we demonstrate that human TbNB has a higher affinity for actin in comparison to Tb4 and promotes cell migration. In combination, this experimentally validates TbNB as functional homologue of rat Tb15 in the human organism and clarifies the current composition of the human Tb family. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Dhaese, S.
Jonckheere, V.
Goethals, M.
Waltregny, David  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Labo de recherche sur les métastases
Vandekerckhove, J.
Ampe, C.
Van Troys, M.
Language :
English
Title :
Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta 15
Publication date :
16 October 2007
Journal title :
FEBS Letters
ISSN :
0014-5793
eISSN :
1873-3468
Publisher :
Elsevier Science Bv, Amsterdam, Netherlands
Volume :
581
Issue :
25
Pages :
4809-4815
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 January 2009

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