Reference : Pleiotropic Mutants Hypersensitive to Heavy Metals and to Oxidative Stress in Chlamydomo...
Scientific journals : Article
Life sciences : Phytobiology (plant sciences, forestry, mycology...)
http://hdl.handle.net/2268/463
Pleiotropic Mutants Hypersensitive to Heavy Metals and to Oxidative Stress in Chlamydomonas Reinhardtii
English
Hanikenne, Marc mailto [Université de Liège - ULg > > Génétique des microorganismes >]
Matagne, René F. [Université de Liège - ULg > > Génétique des microorganismes > >]
Loppes, Roland [Université de Liège - ULg > > Génétique des microorganismes >]
2001
FEMS Microbiology Letters
Blackwell Publishing
196
2
Yes (verified by ORBi)
International
0378-1097
1574-6968
Oxford
United Kingdom
[en] Insertional mutagenesis was used in Chlamydomonas reinhardtii to isolate original mutants hypersensitive to multiple drugs and physical agents. Out of 5200 transformants analyzed, 13 mutants belonging to seven phenotypic classes were isolated. Five were exclusively sensitive to cadmium and represented two loci. The other mutants were pleiotropic and presented a cross sensitivity to several (2--6) of the following agents: cadmium, copper, lead, paraquat, hydrogen peroxide, UVC and light. In all mutants analyzed, the hypersensitive phenotype was most probably due to a single mutational event. The sensitivity of several pleiotropic mutants to a broad range of physical and chemical agents suggests that the disrupted genes are involved in multiple stress responses.
Researchers
http://hdl.handle.net/2268/463

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