ORBi: Kramar G. - Anti-Ia treatment prevents lupus-like autoimmune syndrome in mice neonatally tolerized to alloantigens.

Reference : Anti-Ia treatment prevents lupus-like autoimmune syndrome in mice neonatally tolerized t...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/2268/4602

Title :	Anti-Ia treatment prevents lupus-like autoimmune syndrome in mice neonatally tolerized to alloantigens.
Language :	English
Author, co-author :	Kramar, G. [World Health Organization-Immunology Research and Training Center, Department of Pathology, CMU, 1211 Geneva 4, Switzerland > > > >]
	Schurmans, Stéphane [Université Libre de Bruxelles - ULB > Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Institut de Biologie et de Médecine Moléculaire > > >]
	Aguado, T. [> >]
	Izui, S. [> >]
	del Guidice, G. [> >]
	Lambert, P. H. [World Health Organization-Immunology Research and Training Center, Department of Pathology, CMU, 1211 Geneva 4, Switzerland > > > >]
Publication date :	1993
Journal title :	Journal of Autoimmunity
Publisher :	Academic Press
Volume :	1
Pages :	27-37
Audience :	International
ISSN :	0896-8411
City :	London
Country :	United Kingdom
Keywords :	[en] autoimmune syndrome ; alloantigens ; mice ; treatment
Abstract :	[en] Neonatal injection of semi-allogeneic F1 spleen cells into newborn parental mice results in induction of tolerance to the corresponding class I alloantigen and chimerism. This state of tolerance is associated with the development of a transient lupus-like autoimmune syndrome. Previous experiments performed in our laboratories have shown that host CD4+ T lymphocytes and donor B cells persist in the host and are essential in triggering the autoimmune syndrome observed in neonatally tolerized mice. In this study, we show that early treatment of tolerized mice with anti-donor MHC class II mAb totally prevents the lupus-like syndrome. Moreover, delayed treatment significantly decreases, but to a lesser extent, autoimmune pathological features in tolerized mice. Taken together, these results show that lupus-like autoimmune syndrome developed by neonatally tolerized mice is efficiently prevented by anti-Ia treatment without interfering with the induction of tolerance
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/4602
DOI :	10.1006/jaut.1993.1003

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