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Regulation of Ion Uptake in Membrane Vesicles from Rat Brain by Thiamine Compounds
Bettendorff, Lucien; Wins, Pierre; Schoffeniels, Ernest
1990In Biochemical and Biophysical Research Communications, 171 (3), p. 1137-1144
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Abstract :
[en] We examined the effects of thiamine derivatives on ion uptake in rat brain membrane vesicles. Thiamine triphosphate (1 mM) and pyrithiamine (0.1 mM) increase chloride uptake. Preincubation of crude homogenate with thiamine or pyrithiamine increases chloride uptake while oxythiamine has the reverse effect. Thiamine and oxythiamine also affect 22Na+ and 86Rb+ uptake in the same way as for 36Cl- but to a lesser extent. Thiamine-dependent 36Cl- uptake is activated by sodium bicarbonate (10 mM) and partially inhibited by bumetanide (0.1 mM) and 2,4-dinitrophenol (0.1 mM). Preincubation with thiamine increases the thiamine triphosphate content of the vesicles. The hypothesis that TTP is the activator of a particular chloride uptake mechanism is discussed.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bettendorff, Lucien  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Wins, Pierre
Schoffeniels, Ernest
Language :
English
Title :
Regulation of Ion Uptake in Membrane Vesicles from Rat Brain by Thiamine Compounds
Publication date :
1990
Journal title :
Biochemical and Biophysical Research Communications
ISSN :
0006-291X
eISSN :
1090-2104
Publisher :
Elsevier, Atlanta, United States - California
Volume :
171
Issue :
3
Pages :
1137-1144
Peer reviewed :
Peer reviewed
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