[en] The effect of intermittent light stimulation (ILS) on the distribution of thiamine derivatives in three brain areas (occipital, motor, and premotor) was compared in photosensitive and nonphotosensitive baboons. ILS induces paroxysmal discharges in the motor and premotor areas of photosensitive animals only. In baboons submitted to ILS, thiamine triphosphate (TTP) decreases in both photosensitive and nonphotosensitive animals; thiamine monophosphate (TMP) increases in photosensitive animals, which present ILS-induced paroxysmal discharges, whereas it is unaffected in nonphotosensitive animals. The variations are the most significant in the occipital (visual) cortex. A consumption of TTP may result from electrical activity induced by light stimulation in the occipital area. No correlation between ILS-induced paroxysmal activity and a decrease in TTP contents was found. However, photosensitive animals are affected differently from nonphotosensitive animals, as their content of TMP in the cerebral cortex increases on stimulation. However, as long as the exact role of thiamine compounds in relation to membrane excitability in the nervous system remains unknown, it is impossible to conclude whether the differences observed in the metabolism of thiamine compounds are the cause or the consequence of the photosensitivity in the baboon Papio papio.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bettendorff, Lucien ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Schoffeniels, Ernest
Naquet, R.
Silva-Barrat, C.
Riche, D.
Menini, C.
Language :
English
Title :
Phosphorylated Thiamine Derivatives and Cortical Activity in the Baboon Papio Papio: Effect of Intermittent Light Stimulation
Ancri D., Naquet R., Menini C, Meldrum B.S., Stutzmann J.M., Basset J.Y. (1981) Cerebral and extra‐cerebral blood volume in generalized seizures in the baboon Papio papio. Electroen-cephalogr. Clin. Neurophysiol. 51:91-103.
Balzamo E., Bert J., Menini C, Naquet R. (1975) Excessive light sensitivity in Papio papio: its variations with age, sex and geographic origin. Epilepsia 16:269-276.
Bettendorff L., Grandfils C, De Rycker G, Schoffeniels E. (1986) Determination of thiamine and its phosphate esters in human blood serum at femtomole levels. J. Chromatogr. 382:297-302.
Bettendorff L., Michel‐Cahay C, Grandfils C, De Rycker C, Schoffeniels E. (1987) Thiamine triphosphate and membrane‐associated thiamine phosphatases in the electric organ of. Elec-trophorus electricus. J. Neurochem. 49:495-502.
Bettendorff L., Wins P., Schoffeniels E. (1988) Thiamine triphosphatase from Electrophones electricus electric organ is anion‐dependent and irreversibly inhibited by 4,4′‐diisothiocyano‐stilbene‐2,2′‐disulfonic acid. Biochem. Biophvs. Res, Commun. 154:942-947.
Bontemps J., Philippe P., Bettendorff L., Lombet J., Dandrifosse G., Schoffeniels E., Crommen J. (1984) Determination of thiamine and thiamine phosphates in excitable tissues as thiochrome derivatives by reversed‐phase high‐performance liquid chromatography on octadecyl silica. J. Chromatogr. 307:283-294.
Bryere P., Silva‐Barrat C, Rabending G., Kajima M., Lepoivre‐Maire E., Menini C. (1986) The influence of light stimulation on subcortical potentials evoked by single flashes in photosensitive Papio papio. Epilepsia 27:10-18.
Cooper J.R., Pincus J.H. (1979) The role of thiamine in nervous tissue. Neurochem. Res. 4:223-239.
Eder L., Dunant Y. (1980) Thiamine and cholinergic transmission in the electric organ of Torpedo. I. Cellular localization and functional changes of thiamine and thiamine phosphate esters. J. Neurochem. 35:1278-1286.
Fischer‐Williams M., Poncet M., Riche D., Naquet R. (1968) Light‐induced epilepsy in the baboon Papio papio: cortical and depth recordings. Electroencephalogr. Clin. Neurophysiol. 25:557-569.
Gaitonde M.K., Evans G.M. (1983) Metabolism of thiamine in rat brain in vivo. Biochemical Society Transactions 11:695-696.
Thiamine, Gubler C. J., Fujiwara M., Dreyfus P. M., John Wiley, New York; 1976.
Ishii K., Sarai K., Sanemori H., Kawasaki T. (1979) Analysis of thiamine and its phosphate esters by high‐performance liquid chromatography. Anal. Biochem. 97:191-195.
Itokawa Y., Cooper J.R. (1969) Thiamine release from nerve membranes by tetrodotoxin. Science 166:759-760.
Itokawa Y., Cooper J.R. (1970) Ion movements and thiamine in nervous tissue. I. Intact nerve preparation. Biochem. Pharmacol. 19:985-992.
Kawasaki T, Sanemori H. (1985) Vitamine Bl: thiamines. Modern Chromatographic Analysis of the Vitamines , De Leen‐heer A. P., Lambert W. E., De Ruyter M. G. M., eds, pp., Marcel Dekker, New York and Basel; 385-411.
Killam K.F., Killam E.K., Naquet R. (1967) An animal model of light sensitive epilepsy. Electroencephalogr. Clin. Neurophysiol. 22:497-513.
Lloyd K.G., Scatton B., Voltz C, Bryere P., Valin A., Naquet R. (1986) CSF amino acid and monoamine metabolite levels of Papio papio: correlation with photosensitivity. Brain Res. 363:390-394.
Matsuda T., Cooper J.R. (1981) The separation and determi‐nation of thiamine and its phosphate esters in brain. Anal. Biochem. 117:203-207.
Meldrum B.S., Brailowsky S., Naquet R. (1978) Approche phar‐macologique de ľépilepsie photosensible de Papio papio. Actual. Pharmacol. 8:81-99.
Ménini C., Naquet R. (1980) Generalized photosensitive epilepsy in the Senegalese baboon {Papio papio). Advances in Epilep‐tology , Canger R., Angeleri R, Penry K., eds, pp., Raven Press, New York; 265-272.
Menini C, Silva‐Comte C, Stutzmann J.M, Dimov S. (1981) Cortical unit discharges during photic intermittent stimulation in the Papio papio. Relationships with paroxysmal fronto‐ro‐landic activity. Electroencephalogr. Clin. Neurophysiol. 52:42-49.
Minz B. (1938) Sur la libération de la vitamine Bl par le tronc isolé du nerf pneumogastrique soumis à Fexcitation électrique. C. R. Soc. Biol. Filial. 127:1251-1253.
Olempska‐Beer Z., Freese E.B. (1984) Optimal extraction conditions for high performance liquid chromatographic determination of nucleotides in yeast. Anal. Biochem. 140:236-245.
(1982) Thiamine. Twenty years of progress. Ann. NY Acad. Sci. , Sable H. Z., Gubler C. J.; 378.
Siesjo B.K. Brain Energy Metabolism, J. Wiley and Sons, New York; 1978.
Silva‐Barrat C, Ménini C, Bryere P., Naquet R. (1986) Mul‐tiunitary activity analysis of cortical and subcortical structures in paroxysmal discharges and grand mal seizures in photosensitive baboons. Electroencephalography and Clinical Neurophysiology 64:455-468.
Silva‐Barrat C, Brailowsky S., Levesque G., Ménini C. (1988) Epileptic discharges induced by intermittent light stimulation in photosensitive baboons: a current source density study. Epilepsy Research 2:1-8.
Silva‐Comte G, Velluti J., Ménini C. (1982) Characteristics and origin of frontal paroxysmal responses induced by light stimulation in the Papio papio under allylglycine. Electroencephalogr. Clin. Neurophysiol. 53:479-490.
von Muralt A. (1947) Thiamine and peripheral neurophysiology. Vitam. Horm. 5:93-118.
