Reference : The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/4518
The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation
English
[fr] La protéine adaptatrice CIKS/Act1 est essentielle pour l'allergie inflammatoire déclenchée par la cytokine IL-25
Claudio, Estefania [National Institutes of Health > Laboratory of Immunoregulation]
Sonder, Soren Ulrik [National Institutes of Health > Laboratory of Immunoregulation]
Saret, Sun [National Institutes of Health > Laboratory of Immunoregulation]
Carvalho, Gabrielle [National Institutes of Health > Laboratory of Immunoregulation]
Ramalingam, Thirumalai R. [National Institutes of Health > Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases]
Wynn, Thomas A. [National Institutes of Health > Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Garcia-Perganeda, Antonio [National Institutes of Health > Laboratory of Immunoregulation]
Leonardi, Antonio [National Institutes of Health > Laboratory of Immunoregulation]
Paun, Andrea [National Institutes of Health > Laboratory of Immunoregulation]
Chen, Amy [National Institutes of Health > National Human Genome Research Institute]
Ren, Nina Y. [National Institutes of Health > Laboratory of Immunoregulation]
Wang, Hongshan [National Institutes of Health > Laboratory of Immunoregulation]
Siebenlist, Ulrich [National Institutes of Health > Laboratory of Immunoregulation]
2009
Journal of Immunology
American Association of Immunologists
182
1617-1639
Yes (verified by ORBi)
International
0022-1767
1550-6606
Baltimore
MD
[en] CIKS/Act1 ; Allergie inflammatoire ; IL-25
[en] IL-17 is the signature cytokine of recently discovered Th type 17 (Th17) cells, which are prominent in defense against extracellular bacteria and fungi as well as in autoimmune diseases, such as rheumatoid arthritis and experimental autoimmune encephalomyelitis in animal models. IL-25 is a member of the IL-17 family of cytokines, but has been associated with Th2 responses instead and may negatively cross-regulate Th17/IL-17 responses. IL-25 can initiate an allergic asthma-like inflammation in the airways, which includes recruitment of eosinophils, mucus hypersecretion, Th2 cytokine production, and airways hyperreactivity. We demonstrate that these effects of IL-25 are entirely dependent on the adaptor protein CIKS (also known as Act1). Surprisingly, this adaptor is necessary to transmit IL-17 signals as well, despite the very distinct biologic responses that these two cytokines elicit. We identify CD11c(+) macrophage-like lung cells as physiologic relevant targets of IL-25 in vivo.
GIGA-Signal Transduction
FNRS, TELEVIE, FBC, Fonds Léon Frédéricq, PAI phase VI, ARC
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/4518

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