Reference : Transient T and B cell activation after neonatal induction of tolerance to MHC class ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/4482
Transient T and B cell activation after neonatal induction of tolerance to MHC class II and Mls alloantigens
English
Schurmans, Stéphane mailto [Université Libre de Bruxelles - ULB > Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Institut de Biologie et de Médecine Moléculaire > > >]
Brighouse, G. [Department of Pathology, CMU, Geneva, Switzerland > > > >]
Kramar, G. [Department of Pathology, CMU, Geneva, Switzerland > > > >]
Wen, L. [Department of Pathology, CMU, Geneva, Switzerland > > > >]
Izui, S. [Department of Pathology, CMU, Geneva, Switzerland > > > >]
Merino, J. [Department of Pathology, CMU, Geneva, Switzerland > > > >]
Lambert, P. H. [Department of Pathology, CMU, Geneva, Switzerland > > > >]
1991
Journal of Immunology
American Association of Immunologists
146
2152-2160
Yes (verified by ORBi)
International
0022-1767
1550-6606
Baltimore
MD
[en] Transient T and B cell ; neonatal induction ; tolerance ; MHC class II ; alloantigens
[en] The neonatal injection of semiallogeneic F1 spleen cells into newborn parental mice results in the induction of tolerance to the corresponding alloantigen (alloAg) and chimerism. In these F1 cell-injected mice, we have previously observed that this state of specific tolerance is associated with the development of a transient lupus-like autoimmune syndrome. In this study, we show that neonatal injection of mice with spleen cells differing from the host at major histocompatibility complex (MHC) class I, class II, class (I + II), or minor lymphocyte stimulating (Mls) alloAg induced a state of specific tolerance characterized by the absence of alloreactive CTL and/or Th cell responses in the spleen and the thymus of 6- to 12-week-old injected mice. However, in mice rendered tolerant to MHC class II or class (I + II) alloAg, the presence of high levels of IgG1 antibodies, of circulating immune complexes, of anti-ssDNA autoantibodies, and of tissue lesions were transiently observed. In these mice, an increased Ia Ag expression on lymphoid spleen cells was also detected at 1 wk. The elevated production of IgG1 and the overexpression of Ia Ag were almost completely prevented by treatment with an anti-IL-4 mAb. Such manifestations of B cell activation and autoimmunity were not observed in mice neonatally injected with F1 cells differing from the host only at MHC class I Ag. In mice neonatally tolerized to Mls Ag, a transient increase in IgG2a production and an overexpression of Ia Ag were detected without features of autoimmunity, and were prevented by anti-INF-gamma mAb treatment. In mice rendered tolerant to MHC class II, class (I + II), or Mls alloAg at birth, the manifestations of B cell activation were associated with the presence of in vivo-activated alloreactive CD4+ T cells in the spleen--but not the thymus--of 1-wk-old injected mice. Together, these results suggest that in mice neonatally injected with semiallogeneic F1 cells, the process of tolerance induction is not efficient during the early postnatal period, and could allow the maturation and peripheralization of some alloreactive CD4+ T cells, leading to transient B cell activation and, depending on the alloAg, to autoimmunity
Researchers ; Professionals
http://hdl.handle.net/2268/4482

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