Article (Scientific journals)
Macromolecular engineering of polylactones and polylactides. 23. Synthesis and characterization of biodegradable and biocompatible homopolymers and block copolymers based on 1,4,8-trioxal [4.6] spiro-9-undecanone
Tian, Dong; Dubois, Philippe; Jérôme, Robert
1997In Macromolecules, 30 (7), p. 1947-1954
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Keywords :
ring-opening polymerization (ROP); lactone
Abstract :
[en] Homopolymers of 1,4,8-trioxa[4.6]spiro-9-undecanone (TOSUO) and block copolymers of TOSUO and ε-caprolactone (ε-CL) have been synthesized with aluminum isopropoxide as an initiator in toluene at 25 °C. The homopolymerization is first order with respect to both monomer and initiator, and the end-group analysis agrees with a coordination−insertion mechanism based on the acyl-oxygen cleavage of the TOSUO ring. Living poly(ε-caprolactone) (PCL) and poly(1,4,8-trioxa[4.6]spiro-9-undecanone) (PTOSUO) chains are very efficient macroinitiators for the polymerization of TOSUO and ε-CL, respectively, with formation of block copolymers of a narrow molecular weight distribution. Size-exclusion chromatography (SEC) and 13C-NMR confirm the blocky structure of the copolymers, in agreement with DSC, which shows two glass transitions characteristic of the amorphous phase of PCL and PTOSUO, respectively. The ethylene ketal pendent groups of the PTOSUO block have been successfully converted to ketones and hydroxyl pendent groups without scission of the polyester backbone. These new materials have potential for applications in medicine, surgery, and tissue engineering.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Tian, Dong;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Dubois, Philippe ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Robert ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Macromolecular engineering of polylactones and polylactides. 23. Synthesis and characterization of biodegradable and biocompatible homopolymers and block copolymers based on 1,4,8-trioxal [4.6] spiro-9-undecanone
Publication date :
07 April 1997
Journal title :
Macromolecules
ISSN :
0024-9297
eISSN :
1520-5835
Publisher :
Amer Chemical Soc, Washington, United States - Washington
Volume :
30
Issue :
7
Pages :
1947-1954
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
Available on ORBi :
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