|Reference : The influence of cortical perforations and of space filling with peripheral blood on the...|
|Scientific journals : Article|
|Human health sciences : Dentistry & oral medicine|
|The influence of cortical perforations and of space filling with peripheral blood on the kinetics of guided bone generation. A comparative histometric study in the rat.|
|Rompen, Eric [Centre Hospitalier Universitaire de Liège - CHU > > Médecine dentaire >]|
|Biewer, Robert [> > > >]|
|Van Heusden, Alain [Centre Hospitalier Universitaire de Liège - CHU > > Institut de dentisterie - prothèse fixée >]|
|Zahedi, Sharham [> > > >]|
|Nusgens, Betty [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]|
|Clinical Oral Implants Research|
|Munksgaard International Publishers|
|Yes (verified by ORBi)|
|[en] Animals ; Blood Coagulation ; Bone Regeneration ; Connective Tissue/physiology ; Guided Tissue Regeneration/methods ; Neovascularization, Physiologic ; Osteoblasts ; Osteogenesis ; Rats ; Rats, Wistar ; Skull ; Titanium|
|[en] The aim of the present study was to evaluate the influence of cortical perforations and of peripheral blood addition in guided bone generation beyond the skeletal envelope in rats. A total of 30 isogenic adult rats were divided into 3 equal groups. In each rat, two hollow parallelipipedic titanium chambers were placed bilaterally on the calvaria after a periosteal skin flap was raised. While on the right sides (controls) the osseous surface was left intact and the chambers were empty, the cortical bone under the left-side chambers (test sites) was perforated with nine 0.8 mm-diameter holes (group I), or left intact but with the chambers filled with a clot of peripheral blood (group II). In group III, both procedures were combined in the test sites. The healing was assessed at 4, 8 and 16 weeks after surgery by histologic and computer-assisted histometric analysis. The results demonstrated a substantial augmentation of on average 141% (SD 18) of the skull's thickness after 16 weeks in the controls, indicating that a predictable bone formation can be achieved beneath completely occlusive barriers over a non-injured cortical layer. In all test groups, a significantly larger bone augmentation was observed after 16 weeks compared to the control sites 172.8% (SD 41.7) in group I (P < 0.05), 172.0% (SD 18.4) in group II (P < 0.05) and 221.5% (SD 42.3) in group III (P < 0.001), demonstrating that stimulating blood supply and bone forming cells access by cortical perforations and/or blood clot addition enhances de novo bone formation in this experimental model.|
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