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The influence of cortical perforations and of space filling with peripheral blood on the kinetics of guided bone generation. A comparative histometric study in the rat.
Rompen, Eric; Biewer, Robert; Van Heusden, Alain et al.
1999In Clinical Oral Implants Research, 10 (2), p. 85-94
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Keywords :
Animals; Blood Coagulation; Bone Regeneration; Connective Tissue/physiology; Guided Tissue Regeneration/methods; Neovascularization, Physiologic; Osteoblasts; Osteogenesis; Rats; Rats, Wistar; Skull; Titanium
Abstract :
[en] The aim of the present study was to evaluate the influence of cortical perforations and of peripheral blood addition in guided bone generation beyond the skeletal envelope in rats. A total of 30 isogenic adult rats were divided into 3 equal groups. In each rat, two hollow parallelipipedic titanium chambers were placed bilaterally on the calvaria after a periosteal skin flap was raised. While on the right sides (controls) the osseous surface was left intact and the chambers were empty, the cortical bone under the left-side chambers (test sites) was perforated with nine 0.8 mm-diameter holes (group I), or left intact but with the chambers filled with a clot of peripheral blood (group II). In group III, both procedures were combined in the test sites. The healing was assessed at 4, 8 and 16 weeks after surgery by histologic and computer-assisted histometric analysis. The results demonstrated a substantial augmentation of on average 141% (SD 18) of the skull's thickness after 16 weeks in the controls, indicating that a predictable bone formation can be achieved beneath completely occlusive barriers over a non-injured cortical layer. In all test groups, a significantly larger bone augmentation was observed after 16 weeks compared to the control sites 172.8% (SD 41.7) in group I (P < 0.05), 172.0% (SD 18.4) in group II (P < 0.05) and 221.5% (SD 42.3) in group III (P < 0.001), demonstrating that stimulating blood supply and bone forming cells access by cortical perforations and/or blood clot addition enhances de novo bone formation in this experimental model.
Disciplines :
Dentistry & oral medicine
Author, co-author :
Rompen, Eric ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine dentaire
Biewer, Robert 
Van Heusden, Alain ;  Centre Hospitalier Universitaire de Liège - CHU > Institut de dentisterie - prothèse fixée
Zahedi, Sharham 
Nusgens, Betty ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
The influence of cortical perforations and of space filling with peripheral blood on the kinetics of guided bone generation. A comparative histometric study in the rat.
Publication date :
1999
Journal title :
Clinical Oral Implants Research
ISSN :
0905-7161
eISSN :
1600-0501
Publisher :
Munksgaard International Publishers, Copenhagen, Denmark
Volume :
10
Issue :
2
Pages :
85-94
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 January 2009

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