ORBi: Rompen Eric - The influence of cortical perforations and of space filling with peripheral blood on the kinetics of guided bone generation. A comparative histometric study in the rat.

Reference : The influence of cortical perforations and of space filling with peripheral blood on the...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Dentistry & oral medicine
	To cite this reference:	http://hdl.handle.net/2268/4437

Title :	The influence of cortical perforations and of space filling with peripheral blood on the kinetics of guided bone generation. A comparative histometric study in the rat.
Language :	English
Author, co-author :	Rompen, Eric [Centre Hospitalier Universitaire de Liège - CHU > > Médecine dentaire >]
	Biewer, Robert [> > > >]
	Van Heusden, Alain [Centre Hospitalier Universitaire de Liège - CHU > > Institut de dentisterie - prothèse fixée >]
	Zahedi, Sharham [> > > >]
	Nusgens, Betty [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Publication date :	1999
Journal title :	Clinical Oral Implants Research
Publisher :	Munksgaard International Publishers
Volume :	10
Issue/season :	2
Pages :	85-94
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0905-7161
e-ISSN :	1600-0501
City :	Copenhagen
Country :	Denmark
Keywords :	[en] Animals ; Blood Coagulation ; Bone Regeneration ; Connective Tissue/physiology ; Guided Tissue Regeneration/methods ; Neovascularization, Physiologic ; Osteoblasts ; Osteogenesis ; Rats ; Rats, Wistar ; Skull ; Titanium
Abstract :	[en] The aim of the present study was to evaluate the influence of cortical perforations and of peripheral blood addition in guided bone generation beyond the skeletal envelope in rats. A total of 30 isogenic adult rats were divided into 3 equal groups. In each rat, two hollow parallelipipedic titanium chambers were placed bilaterally on the calvaria after a periosteal skin flap was raised. While on the right sides (controls) the osseous surface was left intact and the chambers were empty, the cortical bone under the left-side chambers (test sites) was perforated with nine 0.8 mm-diameter holes (group I), or left intact but with the chambers filled with a clot of peripheral blood (group II). In group III, both procedures were combined in the test sites. The healing was assessed at 4, 8 and 16 weeks after surgery by histologic and computer-assisted histometric analysis. The results demonstrated a substantial augmentation of on average 141% (SD 18) of the skull's thickness after 16 weeks in the controls, indicating that a predictable bone formation can be achieved beneath completely occlusive barriers over a non-injured cortical layer. In all test groups, a significantly larger bone augmentation was observed after 16 weeks compared to the control sites 172.8% (SD 41.7) in group I (P < 0.05), 172.0% (SD 18.4) in group II (P < 0.05) and 221.5% (SD 42.3) in group III (P < 0.001), demonstrating that stimulating blood supply and bone forming cells access by cortical perforations and/or blood clot addition enhances de novo bone formation in this experimental model.
Permalink :	http://hdl.handle.net/2268/4437

There is no file associated with this reference.

All documents in ORBi are protected by a user license.

Dspace v1.5