Reference : Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's...
Scientific journals : Article
Life sciences : Genetics & genetic processes
Human health sciences : Gastroenterology & hepatology
http://hdl.handle.net/2268/4413
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
English
Barrett, Jeffrey C. [> > > >]
Hansoul, Sarah [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Nicolae, Dan L. [> > > >]
Cho, Judy H [> > > >]
Duerr, Richard H [> > > >]
Rioux, John D. [> > > >]
Brant, Steven R. [> > > >]
Silverberg, Mark S. [> > > >]
Taylor, Kent D. [> > > >]
Barmada, M. Michaël [> > > >]
Bitton, Alain [> > > >]
Dassopoulos, Themistocles [> > > >]
Wu Datta, Lisa [> > > >]
Green, Todd [> > > >]
Griffiths, Anne M. [> > > >]
Kistner, Emily O. [> > > >]
Murtha, Michaël T. [> > > >]
Regueiro, Miguel D. [> > > >]
Rotter, Jérôme I. [> > > >]
Schumm, L. Philip [> > > >]
Steinhart, A. Hillary [> > > >]
Targan, Stephan R. [> > > >]
Xavier, Ramnik J. [> > > >]
Libioulle, Cécile mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Sandor, Cynthia mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Lathrop, Mark [> >]
Belaiche, Jacques mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Dewit, Olivier [> >]
Gut, Ivo [> >]
Heath, Simon [> >]
Laukens, Debby [> >]
Mni, Myriam [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale]
Rutgeerts, Paul [> >]
Van Gossum, André [> >]
Zelenika, Diana [> >]
Franchimont, Denis [> >]
Hugot, Jean-Pierre [> > > >]
de Vos, Martine [> >]
Vermeire, Séverine [> >]
Louis, Edouard mailto [Université de Liège - ULg > Département des sciences cliniques > Hépato-gastroentérologie >]
Cardon, Lon R. [> >]
Anderson, Carl A. [> >]
Drummond, Hazel [> >]
Nimmo, Elaine [> >]
Ahmad, Tariq [> >]
Prescott, Natalie J. [> >]
Onnie, Clive M. [> >]
Fisher, Sheila A. [> >]
Marchini, Jonathan [> >]
Ghori, Jilur [> >]
Bumpstead, Suzannah [> >]
Gwilliam, Rhian [> >]
Tremelling, Mark [> >]
Deloukas, Panos [> >]
Mansfield, John [> >]
Jewell, Derek [> >]
Satsangi, Jack [> >]
Mathew, Christopher G. [> >]
Parkes, Miles [> >]
Georges, Michel [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Daly, Mark J. [> >]
2008
Nature Genetics
Nature Publishing Group
40
8
955-62
Yes (verified by ORBi)
International
1061-4036
1546-1718
New York
NY
[en] Crohn Disease/genetics ; Genetic Predisposition to Disease ; Genome, Human ; Humans ; Quantitative Trait Loci
[en] Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.
Researchers ; Professionals
http://hdl.handle.net/2268/4413
also: http://hdl.handle.net/2268/101959
10.1038/ng.175

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