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| Reference : Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's di... |
| Scientific journals : Article | |||
| Life sciences : Genetics & genetic processes Human health sciences : Gastroenterology & hepatology | |||
| http://hdl.handle.net/2268/4413 | |||
| Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | |
| English | |
| Barrett, Jeffrey C. [> > > >] | |
| Hansoul, Sarah [Université de Liège - ULg > Département de productions animales > Génomique animale >] | |
| Nicolae, Dan L. [> > > >] | |
| Cho, Judy H [> > > >] | |
| Duerr, Richard H [> > > >] | |
| Rioux, John D. [> > > >] | |
| Brant, Steven R. [> > > >] | |
| Silverberg, Mark S. [> > > >] | |
| Taylor, Kent D. [> > > >] | |
| Barmada, M. Michaël [> > > >] | |
| Bitton, Alain [> > > >] | |
| Dassopoulos, Themistocles [> > > >] | |
| Wu Datta, Lisa [> > > >] | |
| Green, Todd [> > > >] | |
| Griffiths, Anne M. [> > > >] | |
| Kistner, Emily O. [> > > >] | |
| Murtha, Michaël T. [> > > >] | |
| Regueiro, Miguel D. [> > > >] | |
| Rotter, Jérôme I. [> > > >] | |
| Schumm, L. Philip [> > > >] | |
| Steinhart, A. Hillary [> > > >] | |
| Targan, Stephan R. [> > > >] | |
| Xavier, Ramnik J. [> > > >] | |
Libioulle, Cécile  [Université de Liège - ULg > Département de productions animales > Génomique animale >] | |
| Sandor, Cynthia [Université de Liège - ULg > Département de productions animales > Génomique animale >] | |
| Lathrop, Mark [> >] | |
| Belaiche, Jacques [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >] | |
| Dewit, Olivier [> >] | |
| Gut, Ivo [> >] | |
| Heath, Simon [> >] | |
| Laukens, Debby [> >] | |
| Mni, Myriam [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale] | |
| Rutgeerts, Paul [> >] | |
| Van Gossum, André [> >] | |
| Zelenika, Diana [> >] | |
| Franchimont, Denis [> >] | |
| Hugot, Jean-Pierre [> > > >] | |
| de Vos, Martine [> >] | |
| Vermeire, Séverine [> >] | |
| Louis, Edouard [Université de Liège - ULg > Département des sciences cliniques > Hépato-gastroentérologie >] | |
| Cardon, Lon R. [> >] | |
| Anderson, Carl A. [> >] | |
| Drummond, Hazel [> >] | |
| Nimmo, Elaine [> >] | |
| Ahmad, Tariq [> >] | |
| Prescott, Natalie J. [> >] | |
| Onnie, Clive M. [> >] | |
| Fisher, Sheila A. [> >] | |
| Marchini, Jonathan [> >] | |
| Ghori, Jilur [> >] | |
| Bumpstead, Suzannah [> >] | |
| Gwilliam, Rhian [> >] | |
| Tremelling, Mark [> >] | |
| Deloukas, Panos [> >] | |
| Mansfield, John [> >] | |
| Jewell, Derek [> >] | |
| Satsangi, Jack [> >] | |
| Mathew, Christopher G. [> >] | |
| Parkes, Miles [> >] | |
| Georges, Michel [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >] | |
| Daly, Mark J. [> >] | |
| 2008 | |
| Nature Genetics | |
| Nature Publishing Group | |
| 40 | |
| 8 | |
| 955-62 | |
| International | |
| 1061-4036 | |
| 1546-1718 | |
| New York | |
| NY | |
| [en] Crohn Disease/genetics ; Genetic Predisposition to Disease ; Genome, Human ; Humans ; Quantitative Trait Loci | |
| [en] Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development. | |
| Researchers ; Professionals | |
| http://hdl.handle.net/2268/4413 | |
| also: http://hdl.handle.net/2268/101959 | |
| 10.1038/ng.175 |
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