Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

[en] Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.

Disciplines :

Genetics & genetic processes
Gastroenterology & hepatology

Author, co-author :

Barrett, Jeffrey C.

Hansoul, Sarah ; Université de Liège - ULiège > Département de productions animales > Génomique animale

Nicolae, Dan L.

Cho, Judy H

Duerr, Richard H

Rioux, John D.

Brant, Steven R.

Silverberg, Mark S.

Taylor, Kent D.

Barmada, M. Michaël

More authors (51 more)

Language :

English

Title :

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Publication date :

2008

Journal title :

Nature Genetics

ISSN :

1061-4036

eISSN :

1546-1718

Publisher :

Nature Publishing Group, New York, United States - New York

Volume :

Issue :

Pages :

955-62

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 January 2009

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Scopus citations^®

2227

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