Reference : Influenza A strain-dependent pathogenesis in fatal H1N1 and H5N1 infections of mice
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/4408
Influenza A strain-dependent pathogenesis in fatal H1N1 and H5N1 infections of mice
English
Garigliany, Mutien-Marie mailto [Université de Liège - ULg > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies > >]
Habyarimana, Jean mailto [Université de Liège - ULg > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies > >]
Lambrecht, Bénédicte [Centre d'Etudes et de Recherches Vétérinaires Agronomiques = Centrum voor Onderzoek in Diergeneeskunde en Agrochemie - CERVA=CODA > Virologie > > >]
Van de Paar, Els [Université de Liège - ULg > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies > >]
Cornet, Anne [Université de Liège - ULg > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies > >]
van den Berg, Thierry [Centre d'Etudes et de Recherches Vétérinaires Agronomiques = Centrum voor Onderzoek in Diergeneeskunde en Agrochemie - CERVA=CODA > Virologie > > >]
Desmecht, Daniel mailto [Université de Liège - ULg > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies > >]
Apr-2010
Emerging Infectious Diseases
Centers for Disease Control & Prevention (CDC)
16
4
595-603
Yes (verified by ORBi)
International
1080-6040
1080-6059
Atlanta
GA
[en] influenza ; ARDS ; pneumonia
[en] Two different influenza A viruses showing no pathogenicity towards the laboratory mouse were forced to evolve by serial passaging. Although both adapted viruses evoked diffuse alveolar damage and showed a similar 50% mouse lethal dose and the same peak lung concentration, they elicited dramatically different pathological signatures and ARDS courses. In the absence of any virus labeling, a histologist unaware of which infection he was looking at could readily distinguish infections caused by these two viruses. This suggests that fatal infections caused by different highly virulent influenza A viruses do not necessarily share the same pathogenesis. The different histological pictures shown here refute the hypothesis of a single, universal “cytokine storm” underlying all fatal influenzal diseases. Research is thus crucially needed to identify underlying sets of virulence markers and to examine whether it might be advantageous to tailor treatment to the influenza virus pathotype.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/4408

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