Reference : Insulin Detemir in the Treatment of Type 1 and Type 2 Diabetes
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/4367
Insulin Detemir in the Treatment of Type 1 and Type 2 Diabetes
English
Philips, J. C. mailto [Université de Liège - ULg > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale > > > >]
Scheen, André mailto [Université de Liège - ULg > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale]
2006
Vascular Health and Risk Management
2
3
277-83
Yes (verified by ORBi)
1176-6344
1178-2048
[en] Diabetes mellitus ; Insulin analogue ; Hypoglycaemia
[fr] Insulin detemir ; Insulin therapy
[en] Insulin detemir is a soluble long-acting human insulin analogue at neutral pH with a unique mechanism of action. Following subcutaneous injection, insulin detemir binds to albumin via fatty acid chain, thereby providing slow absorption and a prolonged metabolic effect. Insulin detemir has a less variable pharmacokinetic profile than insulin suspension isophane or insulin ultralente. The use of insulin detemir can reduce the risk of hypoglycemia (especially nocturnal hypoglycemia) in type 1 and type 2 diabetic patients. However, overall glycemic control, as assessed by glycated hemoglobin, is only marginally and not significantly improved compared with usual insulin therapy. The weight gain commonly associated with insulin therapy is rather limited when insulin detemir is used. In our experience, this new insulin analogue is preferably administrated at bedtime but can be proposed twice a day (in the morning and either before the dinner or at bedtime). Detemir is a promising option for basal insulin therapy in type 1 or type 2 diabetic patients.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/4367
http://www.dovepress.com/articles.php?article_id=1427
Copyright © 2008 Dove Press Limited. All rights reserved.

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