ORBi: Bonvoisin Catherine - Polyomavirus in Renal Transplantation: A Hot Problem

Reference : Polyomavirus in Renal Transplantation: A Hot Problem


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Immunology & infectious disease Human health sciences : Urology & nephrology
	To cite this reference:	http://hdl.handle.net/2268/4352

Title :	Polyomavirus in Renal Transplantation: A Hot Problem
Language :	English
Author, co-author :	Bonvoisin, Catherine [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
	Weekers, Laurent [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
	Xhignesse, Patricia [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
	Grosch, Stéphanie [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
	Milicevic, Miroslav [Université de Liège - ULg > Faculté de Médecine > > >]
	Krzesinski, Jean-Marie [Université de Liège - ULg > Département des sciences cliniques > Néphrologie >]
Publication date :	15-Apr-2008
Journal title :	Transplantation
Volume :	85
Issue/season :	7S
Pages :	S42-S48
Audience :	International
ISSN :	0041-1337
Keywords :	[en] Renal transplantation ; BK virus nephropathy ; Decoy cell ; Leflunomide ; Cidofovir
Abstract :	[en] Polyomavirus BK has emerged as an important complication after kidney transplantation. Although, BK nephropathy develops in only1%to5%of renal transplant recipients, its prognosis when present is very poor. The most accepted risk factor is the level of immunosuppressive treatment, but the serostatus of donor and recipient and the absence of human leukocyte antigen C7 in donor and/or recipient influence the BK virus (BKV) reactivation. The gold standard in diagnosing BKV nephropathy (BKVN) continues to be biopsy with use of immunohistochemistry for large T antigens. Urinary decoy cells and blood BKV DNA polymerase chain reaction are used in the screening, but their positive predictive values are poor. However, their use as predictors of the evolution of BKVN is more valuable. The reduction of immunosuppressive therapy currently represents the first-line treatment for BKVN. Cidofovir and leflunomide can be used when BKVN continues to progress. In the event of graft loss, retransplantation is possible with a low risk of recurrence when the infection is no longer active.
Target :	Researchers ; Professionals ; Students ; General public ; Others
Permalink :	http://hdl.handle.net/2268/4352
DOI :	10.1097/TP.0b013e318169c794

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