Article (Scientific journals)
Cystatin C: current position and future prospects.
Séronie-Vivien, Sophie; Delanaye, Pierre; Piéroni, Laurence et al.
2008In Clinical Chemistry and Laboratory Medicine, 46 (12), p. 1664-1686
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Keywords :
cancer; cardiovascular risk; chronic renal failure; creatinine; cystatin C; glomerular filtration rate
Abstract :
[en] Abstract Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology. Clin Chem Lab Med 2008;46:1664-86.
Disciplines :
Laboratory medicine & medical technology
Urology & nephrology
Author, co-author :
Séronie-Vivien, Sophie
Delanaye, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Piéroni, Laurence
Mariat, Christophe
Froissart, Marc
Cristol, Jean-Paul
Language :
English
Title :
Cystatin C: current position and future prospects.
Publication date :
2008
Journal title :
Clinical Chemistry and Laboratory Medicine
ISSN :
1434-6621
eISSN :
1437-4331
Publisher :
Walter de Gruyter, Berlin, Germany
Volume :
46
Issue :
12
Pages :
1664-1686
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 January 2009

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