Reference : Cyproterone and a comparison with its acetate ester
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Physics
http://hdl.handle.net/2268/4244
Cyproterone and a comparison with its acetate ester
English
de Ruyck, J. [> > > >]
de Hassonville, S. H. [> > > >]
Liégeois, Jean-François mailto [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique >]
Wouters, J. [> > > >]
Nov-2005
Acta Crystallographica Section E-Structure Reports Online
Blackwell Publishing
61
Part 11
O3576-O3578
Yes (verified by ORBi)
International
1600-5368
Oxford
[en] The crystal structure of cyproterone (systematic name: 6-chloro-1,2-dihydro-17-hydroxy-30H-cyclopropa[a]pregna-1,4,6- triene-3,20-dione), C22H27ClO3, is compared with cyproterone acetate, a potent anti-androgen steroid. The two compounds adopt a similar conformation, except for the cyclopropyl ring attached to the cyclohexenone ring (ring A). Cyproterone further adopts a crystal packing distinct from that of the acetate form. These differences result from hydrogen bonding between the free hydroxy group and the carbonyl group of ring A.
Researchers ; Professionals
http://hdl.handle.net/2268/4244
10.1107/S1600536805031673

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