Article (Scientific journals)
Cyproterone and a comparison with its acetate ester
de Ruyck, J.; de Hassonville, S. H.; Liégeois, Jean-François et al.
2005In Acta Crystallographica. Section E, Structure Reports Online, 61 (Part 11), p. 3576-O3578
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Abstract :
[en] The crystal structure of cyproterone (systematic name: 6-chloro-1,2-dihydro-17-hydroxy-30H-cyclopropa[a]pregna-1,4,6- triene-3,20-dione), C22H27ClO3, is compared with cyproterone acetate, a potent anti-androgen steroid. The two compounds adopt a similar conformation, except for the cyclopropyl ring attached to the cyclohexenone ring (ring A). Cyproterone further adopts a crystal packing distinct from that of the acetate form. These differences result from hydrogen bonding between the free hydroxy group and the carbonyl group of ring A.
Disciplines :
Physics
Author, co-author :
de Ruyck, J.
de Hassonville, S. H.
Liégeois, Jean-François ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Wouters, J.
Language :
English
Title :
Cyproterone and a comparison with its acetate ester
Publication date :
November 2005
Journal title :
Acta Crystallographica. Section E, Structure Reports Online
ISSN :
1600-5368
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
61
Issue :
Part 11
Pages :
O3576-O3578
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 January 2009

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