|Reference : Exforge® (amlodipine/valsartan combination) in hypertension: the evidence of its therape...|
|Scientific journals : Article|
|Human health sciences : Urology & nephrology|
|Exforge® (amlodipine/valsartan combination) in hypertension: the evidence of its therapeutic impact|
|Krzesinski, Jean-Marie [Université de Liège - ULg > Département des sciences cliniques > Néphrologie >]|
|Cohen, Eric P. [Medical College of Wisconsin, Milwaukee, Wisconsin - USA > Nephrology Division > > >]|
|Core Medical Publishing|
|[en] arterial hypertension ; treatment ; combination therapy ; calcium channel blocker ; amlodipine ; angiotensin II receptor|
Introduction: Hypertension is an important risk factor for cardiovascular disease and its management requires improvement.
New treatment strategies are needed.
Aims: This review analyses one of these strategies, which is the development of effective and safe combination therapy. Indeed, at least
two antihypertensive agents are often needed to achieve blood pressure control. Exforge® (Novartis) is a new drug combination of the
calcium channel blocker, amlodipine, and the angiotensin II receptor blocker, valsartan.
Evidence review: The amlodipine/valsartan combination is an association of two well-known antihypertensive products with specific
targets in cardiovascular protection, namely calcium channel blockade and antagonism of the renin-angiotensin-aldosterone system. This
kind of association, with neutral metabolic properties and significant antihypertensive efficacy, could be a useful new antihypertensive
product. Currently available data have shown that this new combination is well-tolerated and effective even in severe hypertension.
Clinical value: Clinical trials are ongoing for further assessment of the efficacy, compliance, and safety of this combination and its
congeners. No data exist to prove that the amlodipine/valsartan combination is better than other antihypertensive strategies for
cardiovascular or renal protection, but some trials with other combination therapies show such potential advantage.
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