Reference : Meningoradiculoneuritis due to acyclovir-resistant varicella zoster virus in an acqui...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
Meningoradiculoneuritis due to acyclovir-resistant varicella zoster virus in an acquired immune deficiency syndrome patient
Snoeck, R. [Katholieke Universiteit Leuven - KUL > > > > > >]
Gérard, M. [Hôpital Saint-Pierre (Bruxelles) > > > >]
Sadzot-Delvaux, Catherine mailto [Université de Liège - ULg > Département des sciences de la vie > Virologie et immunologie > >]
Andrei, G. [Katholieke Universiteit Leuven - KUL > > > > > >]
Balzarini, J. [Katholieke Universiteit Leuven - KUL > > > > > >]
Reymen, D. [Katholieke Universiteit Leuven - KUL > > > > > >]
Ahadi, N. [Hôpital Saint-Pierre (Bruxelles) > > > > > >]
Debruyn, J. M. [Institut Bordet > > > > > >]
Piette, Jacques [Université de Liège - ULg > Département des sciences de la vie > Virologie - Immunologie >]
Rentier, Bernard mailto [Université de Liège - ULg > Département de Microbiologie > Virologie fondamentale et Immunologie > >]
Clumeck, N. [Hôpital Saint-Pierre (Bruxelles) > > > > > >]
De Clercq, E. [Katholieke Universiteit Leuven - KUL > > > >]
Journal of Medical Virology
Wiley Liss, Inc.
Yes (verified by ORBi)
[en] Varicella zoster virus (VZV) is recognized as one of the major viral pathogens reactivated in patients with the acquired immune deficiency syndrome (AIDS). We report the case of meningoradiculoneuritis in an AIDS patient, associated with the isolation in the cerebrospinal fluid (CSF) of a thymidine kinase (TK)-deficient, acyclovir (ACV)-resistant strain of VZV. Although the virus was sensitive in vitro to phosphonoformate (PFA), the patient did not improve during PFA therapy and finally died. Several VZV strains isolated from this patient (including two isolates from the patient's CSF) were analyzed for their TK activity and subsequently the viral TK gene was sequenced showing a major deletion leading to a truncated protein. Their susceptibility to several antiviral agents including ACV, PFA, (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), 9-beta-D-arabinofuranosyladenine (vidarabine), (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine (HPMPC), and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) was evaluated. All the virus strains isolated from this patient remained sensitive to HPMPA and HPMPC, pointing to the potential usefulness of these acyclic nucleoside phosphonates for the treatment of ACV-resistant VZV infections in immunocompromised patients. (C) 1994 Wiley-Liss, Inc.

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