|Reference : Diversity of mechanisms involved in aromatase regulation and estrogen action in the brain|
|Scientific journals : Article|
|Social & behavioral sciences, psychology : Neurosciences & behavior|
|Diversity of mechanisms involved in aromatase regulation and estrogen action in the brain|
|Charlier, Thierry [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]|
|Cornil, Charlotte [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]|
|Ball, Gregory [> >]|
|Balthazart, Jacques [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]|
|Biochimica et Biophysica Acta - General Subjects|
|[en] aromatase ; non-genomic action of steroids ; steroid receptor coregulator ; preoptic area ; male sexual behavior ; estrogen receptor|
In recent years, the mechanisms through which estrogens modulate neuronal physiology, brain morphology, and behavior have proven to be far more complex than previously thought. For example, a second nuclear estrogen receptor has been identified, a new family of coregulatory proteins regulating steroid-dependent gene transcriptions was discovered and, finally, it has become clear that estrogens have surprisingly rapid effects based on their actions on cell membranes, which in turn result in the modulation of intracellular signaling cascades.
Scope of review
This paper presents a selective review of new findings in this area related to work in our laboratories, focusing on the role of estrogens in the activation of male sexual behavior. Two separate topics are considered. We first discuss functions of the steroid receptor coactivator-1 (SRC-1) that has emerged as a key limiting factor for behavioral effects of estradiol. Knocking-down its expression by antisense oligonucleotides drastically inhibits male-typical sexual behaviors. Secondly, we describe rapid regulations of brain estradiol production by calcium-dependent phosphorylations of the aromatase enzyme, themselves under the control of neurotransmitter activity.
These rapid changes in estrogen bioavailability have clear behavioral consequences. Increases or decreases in estradiol concentrations respectively obtained by an acute injection of estradiol itself or of an aromatase inhibitor lead within 15–30 min to parallel changes in sexual behavior frequencies.
These new controls of estrogen action offer a vast array of possibilities for discrete local controls of estrogen action. They also represent a formidable challenge for neuroendocrinologists trying to obtain an integrated view of brain function in relation to behavior.
|Giga-Neurosciences ; Dept Brain and Psychological Sciences, Johns Hopkins University, Baltimore, MD, USA|
|Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; National Institutes of Health - NIH|
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