[en] dihydroflavopereirine ; sempervirine ; cancer cells in culture ; antimitotic activity ; anhydronium bases ; cytology
[en] The cellular effects of dihydroflavopereirine and sempervirine ( two alkaloids isolated from Loganiaceae) are analysed by cytological methods in experimental tumours cultivated in vitro ( B16 mouse melanoma cells, mouse Ehrlich tumour cells ELT). Under some experimental conditions, a certain degree of antimitotic activity is demonstrated and related to the molecular structure.