Reference : Low-productive alpha-herpesviridae infection in chronic lichenoid dermatoses

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Immunology & infectious disease Human health sciences : Dermatology
	To cite this reference:	http://hdl.handle.net/2268/4137

Title :	Low-productive alpha-herpesviridae infection in chronic lichenoid dermatoses
Language :	English
Author, co-author :	Nikkels, Arjen [Université de Liège - ULg > > Dermatologie >]
	Sadzot-Delvaux, Catherine [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Virologie et immunologie - GIGA-M : Coordination scientifique >]
	Rentier, Bernard [Université de Liège - ULg > Services administratifs généraux > Recteur - GIGA-R : Virologie - Immunologie >]
	Pierard-Franchimont, Claudine [Université de Liège - ULg > > Dermatopathologie >]
	Pierard, Gérald [Université de Liège - ULg > > Dermatopathologie >]
Publication date :	1998
Journal title :	Dermatology : International Journal for Clinical & Investigative Dermatology
Volume :	196
Issue/season :	4
Pages :	442-446
Audience :	International
ISSN :	1018-8665
e-ISSN :	1421-9832
Abstract :	[en] BACKGROUND: Herpes simplex virus (HSV) and Varicella-zoster virus (VZV) are responsible for various atypical mucocutaneous manifestations in the immunosuppressed population. One of the causative pathomechanisms suggests an altered virus-host cell relationship. OBJECTIVE/METHODS: This report investigates by histology, immunohistochemistry and in situ hybridization the histological and virological features of 6 protracted, indolent HSV infections and 2 prolonged zoster infections. RESULTS: Histopathology revealed a lichenoid dermatitis in all patients. Specific HSV-1, HSV-2 and VZV in situ hybridization proved the viral origin of the cutaneous lesions. Immunohistochemical assessment demonstrated the intracellular presence of the HSV glycoproteins gB, gC and gD in epidermal keratinocytes which did not exhibit cytolysis. Similar findings were obtained for the VZV gE and gB. CONCLUSION: These results suggest that in some instances HSV and VZV infections may present a protracted disease course associated with a lichenoid inflammatory pattern and a non-cytolytic virus-host cell relationship.
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/4137

	File(s) associated to this reference
	Fulltext file(s): File Commentary Version Size Access Restricted access Low-productive alpha-Herpesviridae infection in chronic lichenoid dermatoses.pdf Publisher postprint 1.09 MB Request copy

All documents in ORBi are protected by a user license.

 

© ULg Library Network |  Feedback |  ORBi legal notices

Dspace v1.5