ORBi: Rettigner C. - Survival, immune responses and tissue cyst production in outbred (Swiss white) and inbred (CBA/Ca) strains of mice experimentally infected with Neospora caninum tachyzoites

Reference : Survival, immune responses and tissue cyst production in outbred (Swiss white) and inbre...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Veterinary medicine & animal health
	To cite this reference:	http://hdl.handle.net/2268/41284

Title :	Survival, immune responses and tissue cyst production in outbred (Swiss white) and inbred (CBA/Ca) strains of mice experimentally infected with Neospora caninum tachyzoites
Language :	English
Author, co-author :	Rettigner, C. [> > > >]
	Leclipteux, Thierry [Université de Liège - ULg > > UER Opérations >]
	De Meerschman, F. [> > > >]
	Focant, Charles [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire >]
	Losson, Bertrand [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires >]
Publication date :	2004
Journal title :	Veterinary Research
Publisher :	E D P Sciences
Volume :	35
Issue/season :	2, Mar-Apr
Pages :	225-232
Audience :	International
ISSN :	0928-4249
City :	Les Ulis Cedexa
Keywords :	[en] Neospora caninum ; immune response ; resistance ; cyst ; mice
Abstract :	[en] The present work compared inbred (CBA/Ca) and outbred (Swiss white) strains of mice for their capacity to cope with a Neospora caninum infection and to consistently produce tissue cysts. In each experiment Swiss white and CBA/Ca mice were given three different doses of NC-1 tachyzoites. Lymphoproliferative and Immoral responses as well as cytokine production were evaluated eight weeks after infection (PI) whereas tissue cyst production and histopathology were assessed 4, 6 and 10 weeks PI in immunosuppressed mice. Tissue cysts were observed 10 weeks after infection only in CBA/Ca mice receiving the two highest inoculum doses. Furthermore this strain showed the highest specific lymphoproliferative response. A mixed cytokine response with elevated IFN-gamma and fairly low IL-4 and IL-10 secretion was recorded. In both strains, no lesions were observed in the tissues of infected mice. This study indicates that CBA/Ca female mice infected with 5 x 10(6) NC-1 tachyzoites represent a useful model for the study of specific maternal immune responses in pregnant animals.
Permalink :	http://hdl.handle.net/2268/41284
DOI :	10.1051/vetres:2004005

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