Reference : Survival, immune responses and tissue cyst production in outbred (Swiss white) and inbre...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Survival, immune responses and tissue cyst production in outbred (Swiss white) and inbred (CBA/Ca) strains of mice experimentally infected with Neospora caninum tachyzoites
Rettigner, C. [> > > >]
Leclipteux, Thierry [Université de Liège - ULg > > UER Opérations >]
De Meerschman, F. [> > > >]
Focant, Charles mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire >]
Losson, Bertrand mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires >]
Veterinary Research
E D P Sciences
2, Mar-Apr
Yes (verified by ORBi)
Les Ulis Cedexa
[en] Neospora caninum ; immune response ; resistance ; cyst ; mice
[en] The present work compared inbred (CBA/Ca) and outbred (Swiss white) strains of mice for their capacity to cope with a Neospora caninum infection and to consistently produce tissue cysts. In each experiment Swiss white and CBA/Ca mice were given three different doses of NC-1 tachyzoites. Lymphoproliferative and Immoral responses as well as cytokine production were evaluated eight weeks after infection (PI) whereas tissue cyst production and histopathology were assessed 4, 6 and 10 weeks PI in immunosuppressed mice. Tissue cysts were observed 10 weeks after infection only in CBA/Ca mice receiving the two highest inoculum doses. Furthermore this strain showed the highest specific lymphoproliferative response. A mixed cytokine response with elevated IFN-gamma and fairly low IL-4 and IL-10 secretion was recorded. In both strains, no lesions were observed in the tissues of infected mice. This study indicates that CBA/Ca female mice infected with 5 x 10(6) NC-1 tachyzoites represent a useful model for the study of specific maternal immune responses in pregnant animals.

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