Reference : Evaluation of BM-573, a novel TXA(2) synthase inhibitor and receptor antagonist, in a...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/41232
Evaluation of BM-573, a novel TXA(2) synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion
English
Kolh, Philippe mailto [Université de Liège - ULg > Services généraux (Fac. de psycho. et des sc. de l'éducat.) > Relations académiques et scientifiques (Psycho et sc.éduc.) - Relations académiques et scientifiques (Sciences)]
Rolin, S. [> > > >]
Tchana-Sato, Vincent [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
Petein, M. [> > > >]
Ghuysen, Alexandre mailto [Université de Liège - ULg > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière]
Lambermont, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Hanson, Julien mailto [Université de Liège - ULg > > Chimie pharmaceutique >]
Magis, David mailto [Université de Liège - ULg > Département de mathématique > Département de mathématique >]
Segers, P. [> > > >]
Masereel, B. [> > > >]
D'Orio, Vincenzo mailto [Université de Liège - ULg > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path.]
Dogné, Jean-Michel [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Mar-2006
Prostaglandins & Other Lipid Mediators
Elsevier Science Inc
79
1-2
53-73
Yes (verified by ORBi)
International
1098-8823
New York
[en] thromboxane synthase inhibitor ; thromboxane receptor antagonist ; myocardial ischemia ; reperfusion injury ; contractile function ; hemodynamics ; pig
[en] Aims: To investigate whether BM-573 (N-tert-butyl-N'-[2-(4'-methylphenylam\ino)-5-nitro-benzenesulfonyl]urea), an original combined thromboxane A(2) synthase inhibitor and receptor antagonist, prevents reperfusion injury in acutely ischemic pigs. Methods: Twelve animals were randomly divided in two groups: a control group (n = 6) intravenously infused with vehicle, and a BM-573-treated group (n = 6) infused with BM-573 (10 mg kg(-1) h(-1)). In both groups, the left anterior descending (LAD) coronary artery was Occluded for 60 min and reperfused for 240 min. Either vehicle or BM-573 was infused 30 min before LAD occlusion and throughout the experiment. Platelet aggregation induced by arachidonic acid ex vivo measured was prevented by BM-573. Results: In both groups, LAD occlusion decreased cardiac output, ejection fraction, slope of stroke work-end-diastolic volume relationship, and induced end-systolic pressure-volume relationship (ESPVR) rightward shift, while left ventricular afterload increased. Ventriculo-arterial coupling and mechanical efficiency decreased. In both groups, reperfusion further decreased cardiac output and ejection fraction, while ESPVR displayed a further rightward shift. Ventriculo-arterial coupling and mechanical efficiency remained impaired. Area at risk, evidenced with Evans blue, was 33.2 +/- 3.4% of the LV mass (LVM) in both groups, and mean infarct size, revealed by triphenyltetrazolium chloride (TTC), was 27.3 +/- 2.6% of the LVM in the BM-573-treated group (NS). Histological examination and immunohistochemical identification of desmin revealed necrosis in the anteroseptal region similar in both groups, while myocardial ATP dosages and electron microscopy also showed that BM-573 had no cardioprotective effect. Conclusions: These data suggest that BM-573 failed to prevent reperfusion injury in acutely ischemic pigs. (C) 2005 Elsevier Inc. All rights reserved.
Researchers ; Students
http://hdl.handle.net/2268/41232
10.1016/j.prostaglandins.2005.10.002
http://www.elsevier.com/wps/find/journaldescription.cws_home/525019/description

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Kolh_79_53_2006.pdfPublisher postprint1.05 MBRequest copy
Open access
Kolh_Prostaglandins_2006_79_53.pdfAuthor postprint3.22 MBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.