Article (Scientific journals)
Evaluation of BM-573, a novel TXA(2) synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion
Kolh, Philippe; Rolin, S.; Tchana-Sato, Vincent et al.
2006In Prostaglandins and Other Lipid Mediators, 79 (1-2), p. 53-73
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Keywords :
thromboxane synthase inhibitor; thromboxane receptor antagonist; myocardial ischemia; reperfusion injury; contractile function; hemodynamics; pig
Abstract :
[en] Aims: To investigate whether BM-573 (N-tert-butyl-N'-[2-(4'-methylphenylam\ino)-5-nitro-benzenesulfonyl]urea), an original combined thromboxane A(2) synthase inhibitor and receptor antagonist, prevents reperfusion injury in acutely ischemic pigs. Methods: Twelve animals were randomly divided in two groups: a control group (n = 6) intravenously infused with vehicle, and a BM-573-treated group (n = 6) infused with BM-573 (10 mg kg(-1) h(-1)). In both groups, the left anterior descending (LAD) coronary artery was Occluded for 60 min and reperfused for 240 min. Either vehicle or BM-573 was infused 30 min before LAD occlusion and throughout the experiment. Platelet aggregation induced by arachidonic acid ex vivo measured was prevented by BM-573. Results: In both groups, LAD occlusion decreased cardiac output, ejection fraction, slope of stroke work-end-diastolic volume relationship, and induced end-systolic pressure-volume relationship (ESPVR) rightward shift, while left ventricular afterload increased. Ventriculo-arterial coupling and mechanical efficiency decreased. In both groups, reperfusion further decreased cardiac output and ejection fraction, while ESPVR displayed a further rightward shift. Ventriculo-arterial coupling and mechanical efficiency remained impaired. Area at risk, evidenced with Evans blue, was 33.2 +/- 3.4% of the LV mass (LVM) in both groups, and mean infarct size, revealed by triphenyltetrazolium chloride (TTC), was 27.3 +/- 2.6% of the LVM in the BM-573-treated group (NS). Histological examination and immunohistochemical identification of desmin revealed necrosis in the anteroseptal region similar in both groups, while myocardial ATP dosages and electron microscopy also showed that BM-573 had no cardioprotective effect. Conclusions: These data suggest that BM-573 failed to prevent reperfusion injury in acutely ischemic pigs. (C) 2005 Elsevier Inc. All rights reserved.
Disciplines :
Biochemistry, biophysics & molecular biology
Cardiovascular & respiratory systems
Author, co-author :
Kolh, Philippe  ;  Université de Liège - ULiège > Services généraux (Fac. de psycho. et des sc. de l'éducat.) > Relations académiques et scientifiques (Psycho et sc.éduc.) - Relations académiques et scientifiques (Sciences)
Rolin, S.
Tchana-Sato, Vincent  ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Petein, M.
Ghuysen, Alexandre ;  Université de Liège - ULiège > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière
Lambermont, Bernard  ;  Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine
Hanson, Julien  ;  Université de Liège - ULiège > Chimie pharmaceutique
Magis, David ;  Université de Liège - ULiège > Département de mathématique > Département de mathématique
Segers, P.
Masereel, B.
D'Orio, Vincenzo ;  Université de Liège - ULiège > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path.
Dogné, Jean-Michel ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
Evaluation of BM-573, a novel TXA(2) synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion
Publication date :
March 2006
Journal title :
Prostaglandins and Other Lipid Mediators
ISSN :
1098-8823
Publisher :
Elsevier Science Inc, New York, United States - New York
Volume :
79
Issue :
1-2
Pages :
53-73
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 06 March 2010

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