Reference : Effects of increased afterload on left ventricular performance and mechanical efficie...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/41227
Effects of increased afterload on left ventricular performance and mechanical efficiency are not baroreflex-mediated
English
Kolh, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Service de Biochimie et de Physiologie humaines, normale et pathologique > > >]
Ghuysen, Alexandre mailto [Université de Liège - ULg > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière]
Tchana-Sato, Vincent [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
D'Orio, Vincenzo mailto [Université de Liège - ULg > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path.]
Gérard, Paul mailto [Université de Liège - ULg > Département de mathématique > Statistique (aspects expérimentaux) >]
Morimont, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Limet, Raymond mailto [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique]
Lambermont, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Dec-2003
European Journal of Cardio - Thoracic Surgery
Elsevier Science Bv
24
6
912-919
Yes (verified by ORBi)
International
1010-7940
Amsterdam
[en] autonomic nervous system ; baroreflex ; hemodynamics ; left ventricular function
[en] Objective: To assess baroreflex intervention during increase in left ventricular afterload, we compared the effects of aortic banding on the intact cardiovascular system and under hexamethonium infusion. Methods: Six open-chest pigs, instrumented for measurement of aortic pressure and flow, left ventricular pressure and volume, were studied under pentobarbital-sufentanil anesthesia. Vascular arterial properties were estimated with a four-element windkessel model. Left ventricular contractility was assessed by the slope of end-systolic pressure-volume relationship. Results: The effects of aortic banding on mechanical aortic properties were unaffected by autonomic nervous system inhibition. However, increase in peripheral arterial vascular resistance and in heart rate were prevented by hexamethonium. Aortic banding increased left ventricular contractility and stroke work. Left ventricular-arterial coupling remained unchanged, but mechanical efficiency was impaired. These ventricular changes were independent of baroreflex integrity. Conclusions: Our results demonstrate that an augmentation in afterload has a composite effect on left ventricular function. Left ventricular performance is increased, as demonstrated by increase in contractility and stroke work, but mechanical efficiency is decreased. These changes are observed independently of baroreflex integrity. Such mechanisms of autoregulation, independent of the autonomic nervous system, are of paramount importance in heart transplant patients. (C) 2003 Elsevier B.V. All fights reserved.
http://hdl.handle.net/2268/41227
http://www.elsevier.com/wps/find/journaldescription.cws_home/600127/description#description

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