Reference : Chronic hepatitis C infection in a patient with bone marrow hypoplasia.
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
http://hdl.handle.net/2268/4116
Chronic hepatitis C infection in a patient with bone marrow hypoplasia.
English
Bethlen, S. [> > > >]
Chandrikakumari, Kavitha [> > > >]
de Leval, Laurence mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
GIOT, Jean-Baptiste mailto [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale >]
Mukeba, D. [> > > >]
Leonard, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale >]
Frippiat, Frédéric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale - Direction médicale >]
Meuris, Christel mailto [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale >]
Delwaide, Jean mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
Moutschen, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Immunopathologie - Transplantation >]
2008
World Journal of Gastroenterology
W J G Press
14
26
4238-40
Yes (verified by ORBi)
International
1007-9327
Beijing
China
[en] Bone Marrow/pathology ; Bone Marrow Diseases/complications ; Cryoglobulinemia/etiology ; Female ; Hepatitis C, Chronic/complications ; Humans ; Middle Aged
[en] Chronic hepatitis C virus (HCV) infection is associated with multifarious extra-hepatic manifestations; the most described and discussed being mixed cryoglobulinemia which is strongly related to B-cell lymphoproliferative disorders (LPDs). We present a case of chronic HCV infection and mixed cryoglobulinemia, with minimal liver involvement. The case is a 53-year-old patient who was diagnosed as having bone marrow hypoplasia at the age of three. She received several blood transfusions to normalize her haemoglobin. At the age of 31, she was diagnosed with rheumatoid arthritis on account of her diffuse joint pain and inflammation, elevated rheumatoid factor (RF) and Raynaud's phenomenon. Twenty years later, monoclonal gammopathy of IgG Lambda (one year later, changed to IgM Kappa) was detected during a routine examination. A bone marrow biopsy showed hypoplasia, Kappa positive B-lymphocytes and low-grade malignant lymphoma cells. PCR of the bone marrow aspirate was not contributory. No treatment was initiated owing to her poor bone marrow function and she is under regular follow-up.
http://hdl.handle.net/2268/4116

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