Bone Marrow/pathology; Bone Marrow Diseases/complications; Cryoglobulinemia/etiology; Female; Hepatitis C, Chronic/complications; Humans; Middle Aged
Abstract :
[en] Chronic hepatitis C virus (HCV) infection is associated with multifarious extra-hepatic manifestations; the most described and discussed being mixed cryoglobulinemia which is strongly related to B-cell lymphoproliferative disorders (LPDs). We present a case of chronic HCV infection and mixed cryoglobulinemia, with minimal liver involvement. The case is a 53-year-old patient who was diagnosed as having bone marrow hypoplasia at the age of three. She received several blood transfusions to normalize her haemoglobin. At the age of 31, she was diagnosed with rheumatoid arthritis on account of her diffuse joint pain and inflammation, elevated rheumatoid factor (RF) and Raynaud's phenomenon. Twenty years later, monoclonal gammopathy of IgG Lambda (one year later, changed to IgM Kappa) was detected during a routine examination. A bone marrow biopsy showed hypoplasia, Kappa positive B-lymphocytes and low-grade malignant lymphoma cells. PCR of the bone marrow aspirate was not contributory. No treatment was initiated owing to her poor bone marrow function and she is under regular follow-up.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Bethlen, S.
Chandrikakumari, Kavitha
de Leval, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
GIOT, Jean-Baptiste ; Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale
Mukeba, D.
Leonard, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale
Frippiat, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale - Direction médicale
Meuris, Christelle ; Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale
Delwaide, Jean ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Moutschen, Michel ; Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Transplantation
Language :
English
Title :
Chronic hepatitis C infection in a patient with bone marrow hypoplasia.
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