Reference : Substance P-induced histamine release from human basophils, skin and lung fragments: ...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/4115
Substance P-induced histamine release from human basophils, skin and lung fragments: effect of nedocromil sodium and theophylline.
English
Louis, Renaud mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Radermecker, Maurice [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
1990
International Archives of Allergy and Applied Immunology
Karger
92
4
329-33
Yes (verified by ORBi)
International
0020-5915
Basel
Switzerland
[en] Adult ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Basophils/metabolism ; Female ; Histamine Release/drug effects ; Humans ; Lung/secretion ; Male ; Nedocromil ; Quinolones/pharmacology ; Skin/secretion ; Substance P/pharmacology ; Theophylline/pharmacology
[en] We compared histamine release induced by substance P with those obtained with classical secretagogues on human basophils, lung and skin fragments. We also tested the capacity of nedocromil sodium and theophylline to inhibit histamine release in these 3 experimental models. Substance P (10(-4) M) caused a noncytotoxic histamine release (about 10% of total) from basophils, lung and skin fragments. Substance P-induced histamine release was always smaller than that obtained with optimal doses of anti-IgE, formyl-methionine phenylalanine or compound 48/80. Nedocromil sodium did not prevent secretagogue-induced histamine release from basophils or sliced skin. In contrast, it significantly inhibited anti-IgE- or substance P-induced histamine release from human lung. Theophylline caused a dose-related inhibition on these 3 models. We conclude that substance P is a modest secretagogue for human basophils and mast cells, and that skin and lung mast cells are heterogeneous with respect to their response to nedocromil sodium.
http://hdl.handle.net/2268/4115
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=224161&ContentOnly=false

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