Reference : Substance P-induced histamine release from human basophils, skin and lung fragments: eff...

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Cardiovascular & respiratory systems
	To cite this reference:	http://hdl.handle.net/2268/4115

Title :	Substance P-induced histamine release from human basophils, skin and lung fragments: effect of nedocromil sodium and theophylline.
Language :	English
Author, co-author :	Louis, Renaud [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
	Radermecker, Maurice [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Publication date :	1990
Journal title :	International Archives of Allergy and Applied Immunology
Publisher :	Karger
Volume :	92
Issue/season :	4
Pages :	329-33
Audience :	International
ISSN :	0020-5915
City :	Basel
Country :	Switzerland
Keywords :	[en] Adult ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Basophils/metabolism ; Female ; Histamine Release/drug effects ; Humans ; Lung/secretion ; Male ; Nedocromil ; Quinolones/pharmacology ; Skin/secretion ; Substance P/pharmacology ; Theophylline/pharmacology
Abstract :	[en] We compared histamine release induced by substance P with those obtained with classical secretagogues on human basophils, lung and skin fragments. We also tested the capacity of nedocromil sodium and theophylline to inhibit histamine release in these 3 experimental models. Substance P (10(-4) M) caused a noncytotoxic histamine release (about 10% of total) from basophils, lung and skin fragments. Substance P-induced histamine release was always smaller than that obtained with optimal doses of anti-IgE, formyl-methionine phenylalanine or compound 48/80. Nedocromil sodium did not prevent secretagogue-induced histamine release from basophils or sliced skin. In contrast, it significantly inhibited anti-IgE- or substance P-induced histamine release from human lung. Theophylline caused a dose-related inhibition on these 3 models. We conclude that substance P is a modest secretagogue for human basophils and mast cells, and that skin and lung mast cells are heterogeneous with respect to their response to nedocromil sodium.
Permalink :	http://hdl.handle.net/2268/4115
Other URL :	http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=224161&ContentOnly=false

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