Reference : Increased IL-6 and TGF-beta(1) concentrations in bronchoalveolar lavage fluid associated...
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
Human health sciences : Oncology
http://hdl.handle.net/2268/41099
Increased IL-6 and TGF-beta(1) concentrations in bronchoalveolar lavage fluid associated with thoracic radiotherapy
English
Barthelemy-Brichant, Nicole mailto [Centre Hospitalier Universitaire de Liège - CHU > > >Radiothérapie > > >]
Bosquee, Lionel [Centre Hospitalier Universitaire de Liège - CHU > >]
Cataldo, Didier mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement - Département des sciences biomédicales et précliniques]
Corhay, Jean-Louis mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Gustin, Michel [> > >]
Seidel, Laurence mailto [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique >]
Thiry, Albert mailto [Université de Liège - ULg > > Anatomie pathologique >]
Ghaye, Benoît [Centre Hospitalier Universitaire de Liège - CHU > > Imagerie médicale >]
Nizet, Michel [> > > >]
Albert, Adelin mailto [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique > > >]
Deneufbourg, Jean-Marie mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Bartsch, Pierre mailto [Université de Liège - ULg > > Pneumologie-Allergologie >]
Nusgens, Betty mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire de Biologie des Tissus Conjonctifs > >]
1-Mar-2004
International Journal of Radiation, Oncology, Biology, Physics
Elsevier Science Inc
58
3
758-767
Yes (verified by ORBi)
International
0360-3016
New York
[en] lung ; radiotherapy ; BAL ; IL-6 ; TGF-beta(1)
[en] PURPOSE: To assess, in lung cancer patients, the effects of thoracic radiotherapy (RT) on the concentrations of transforming growth factor-beta(1) (TGF-beta(1)) and interleukin-6 (IL-6) in the bronchoalveolar lavage (BAL) fluid. METHODS AND MATERIALS: Eleven patients with lung cancer requiring RT as part of their treatment were studied. BAL was performed bilaterally before, during, and 1, 3, and 6 months after RT. Before each BAL session, the patient's status was assessed clinically using pulmonary function tests and an adapted late effects on normal tissue-subjective, objective, management, analytic (LENT-SOMA) scale, including subjective and objective alterations. The National Cancer Institute Common Toxicity Criteria were used to grade pneumonitis. The TGF-beta(1) and IL-6 levels in the BAL fluid were determined using the Easia kit. RESULTS: The TGF-beta(1) and IL-6 concentrations in the BAL fluid recovered from the irradiated areas were significantly increased by thoracic RT. The increase in TGF-beta(1) levels tended to be greater in the group of patients who developed severe pneumonitis. In the BAL fluid from the nonirradiated areas, the TGF-beta(1) and IL-6 concentrations remained unchanged. CONCLUSION: The observed increase in TGF-beta(1) and IL-6 concentrations in the BAL fluid recovered from the irradiated lung areas demonstrated that these cytokines may contribute to the process leading to a radiation response in human lung tissue.
Researchers
http://hdl.handle.net/2268/41099
10.1016/S0360-3016(03)01614-6
Copyright 'Int J Rad Oncol Biol PHys'.

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