Article (Scientific journals)
Biopharmaceutical aspects of the development of a sulfamethazine oral sustained release bolus for lambs
Evrard, Brigitte; Delahaut, P.; Hubert, Philippe et al.
1995In Journal of Controlled Release, 35, p. 107-115
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Keywords :
Reticulo-rumen retention; Sulfamethazine; Lipid matrix; Sustained release preparation; Pharmacokinetics
Abstract :
[en] Pharmacokinetic parameters of sulfamethazine (SMZ) administered intravenously or orally either as an aqueous solution or as a lipid matrix formulation, were determined in young lambs. The value of the rate constant for elimination (ke) for the intravenous solution was 0.18 h−1 compared to 0.10 h−1 for the oral aqueous solution. The absolute bioavailability of the oral solution was about 75%. A lipid matrix containing SMZ and a high density excipient is able to be retained in the reticulo-rumen and to produce a sustained release of the drug for at least 100 h provided that the mechanical strength of the bolus is sufficient. The pharmacokinetic data obtained with the lipid matrix show a release profile with two pulses due to both diffusion and erosion mechanisms. Plasma levels are maintained above the MIC of SMZ during 100 h with an absolute bioavailability of 51.7%
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Evrard, Brigitte  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Delahaut, P.
Hubert, Philippe  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Crommen, Jacques ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Delattre, Luc ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
Biopharmaceutical aspects of the development of a sulfamethazine oral sustained release bolus for lambs
Publication date :
1995
Journal title :
Journal of Controlled Release
ISSN :
0168-3659
eISSN :
1873-4995
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
35
Pages :
107-115
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 April 2010

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