[en] The preparation of granules by melt granulation was investigated using a laboratory-scale high-shear mixer (Pellmix PL 1/8) and binary mixtures containing lactose and different lipidic binders, namely, Compritol 888, Cutina HR, or Precirol ATO5.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Amighi, K.
Beten, D.
Delattre, Luc ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Moes, A. J.
Language :
English
Title :
Influence of Melting and Rheological Properties of Fatty Binders on the Melt Granulation Process in a High-Shear Mixer
T. Schaefer, P. Holm, and H. G. Kristensen, Drug Dev. Ind. Pharm., 16, 1249-1277 (1990).
T. Shaefer and Ch. Mathiesen, Int. J. Pharm., 134, 105-117 (1996).
T. Schaefer, B. Taagegaard, L. J. Thomsen, and H. G. Kristensen, Eur. J. Pharm. Sci., 1, 125-131 (1993).
T. Schaefer and Ch. Mathiesen, Int. J. Pharm., 139, 125-138 (1996).
R. Kinget and R. Kernel, Acta Pharm. Technol., 31, 57-62 (1985).
C. A. McTaggart, J. A. Ganley, A. Sickmueller, and S. E. Walker, Int. J. Pharm., 19, 139-148 (1984).
P. Flanders, G. A. Dyer, and D. Jordan, Drug Dev. Ind. Pharm., 13, 1001-1022 (1987).
L. J. Thomsen, T. Schaefer, J. Sonnergaard, and H. G. Kristensen, Drug Dev. Ind. Pharm., 19, 1867-1887 (1993).
B. Evrard and L. Delattre, Drug Dev. Ind. Pharm., 22, 111-118 (1996).
P. V. Parab, C. K. Oh, and W. A. Ritschel, Drug Dev. Ind. Pharm., 12, 1309-1327 (1986).
D. Saraiya and S. Bolton, Drug Dev. Ind. Pharm., 16, 1963-1969 (1990).
S. Malamataris, A. Panagopoulou, and P. Hatzipantou, Drug Dev. Ind. Pharm., 17, 1765-1777 (1991).
M. H. Rubinstein and P. Musikabhuma, Drug Dev. Ind. Pharm., 6, 451-473 (1980).
B. Evrard and L. Delattre, Proc. 6th Int. Conf. Pharm. Technol., 187-196 (1992).
M. G. Boles, P. B. Deasy, and M. F. Donnellan, Drug Dev. Ind. Pharm., 19, 349-370 (1993).
A. N. Ozdemir and I. Agabeyoglu, Drug Dev. Ind. Pharm., 16, 1805-1814 (1990).
A. M. Pommier, C. Brossard, J. Ser, and D. Duchêne, STP Pharma, 4, 384-391 (1988).
H. Bier, H. Leuenberger, and H. Sucker, Pharm. Ind., 41, 375-380 (1979).
P. Holm, High shear mixer granulators, in Handbook of Pharmaceutical Granulation Technology. Drugs and Pharmaceutical Science, Vol. 81 (D. M. Parikh, Ed.), Marcel Dekker, New York, 1997, pp. 151-204.
B. Evrard, Ph.D. thesis, Universite' de Liège, 1995.
C. K. Schoff, Rheological measurements, in Polymers: Polymer Characterization and Analysis (J. I. Kroschwits, Ed.), Wiley Interscience, New York, 1990, pp. 637-725.
M. Djimbo and A. J. Moës, J. Pharm. Belg., 39, 36-42 (1984).
A. J. Moës, Pharm. Acta Helv., 43, 290-320 (1968).
