Reference : Changes in the amygdala amino acid microdialysate after conditioning with a cue associat...
Scientific congresses and symposiums : Paper published in a journal
Human health sciences : Pharmacy, pharmacology & toxicology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/40942
Changes in the amygdala amino acid microdialysate after conditioning with a cue associated with ethanol
English
Quertemont, Etienne mailto [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
de Neuville, Jessica [Université Catholique de Louvain - UCL > > Biologie du Comportement > >]
De Witte, Philippe [Université Catholique de Louvain - UCL > > Biologie du Comportement > >]
1999
Alcohol & Alcoholism
Oxford University Press
34
441
No
No
International
0735-0414
1464-3502
Oxford
United Kingdom
7th Congress of the European Society for Biomedical Research on Alcoholism
European Society for Biomedical Research on Alcoholism (ESBRA)
Barcelona
Spain
[en] Ethanol ; Microdialysis ; Conditioning ; Glutamate ; Taurine ; Amygdala
[en] The excitatory amino acid neurotransmission within the amygdala has been implicated in learning associations between external stimuli and intrinsic reward values such that it may play a key role in conditioned drug effects. In the present studies, the responses of the excitatory amino acids, aspartate and glutamate together with the neuromodulatory sulphonated amino acid taurine, within the basolateral amygdala, to an odor cue repeatedly associated with acute ethanol injections (2g/kg, IP) have been investigated by a microdialysis technique combined with HPLC-EC analysis. After presentation of the ethanol-conditioned stimulus, a single IP saline injection induced an immediate and significant increase in the taurine microdialysate content which could be related to the neuromodulatory action of taurine. Furthermore, when the conditioned stimulus was combined with the ethanol injection (2g/kg, IP), significant increases in both taurine and glutamate microdialysate content were observed and indicated a learned compensatory response to counteract the acute effects of ethanol. These results demonstrate that changes in amygdala extracellular glutamate and taurine concentrations can be conditioned to ethanol-associated stimuli and are therefore probably implicated in the phenomenon of environmental-dependent tolerance to ethanol.
Centre de Neurosciences Cognitives et Comportementales
Researchers ; Professionals
http://hdl.handle.net/2268/40942

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