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Changes in the amygdala amino acid microdialysate after conditioning with a cue associated with ethanol
Quertemont, Etienne; de Neuville, Jessica; De Witte, Philippe
1999In Alcohol and Alcoholism, 34, p. 441
 

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Keywords :
Ethanol; Microdialysis; Conditioning; Glutamate; Taurine; Amygdala
Abstract :
[en] The excitatory amino acid neurotransmission within the amygdala has been implicated in learning associations between external stimuli and intrinsic reward values such that it may play a key role in conditioned drug effects. In the present studies, the responses of the excitatory amino acids, aspartate and glutamate together with the neuromodulatory sulphonated amino acid taurine, within the basolateral amygdala, to an odor cue repeatedly associated with acute ethanol injections (2g/kg, IP) have been investigated by a microdialysis technique combined with HPLC-EC analysis. After presentation of the ethanol-conditioned stimulus, a single IP saline injection induced an immediate and significant increase in the taurine microdialysate content which could be related to the neuromodulatory action of taurine. Furthermore, when the conditioned stimulus was combined with the ethanol injection (2g/kg, IP), significant increases in both taurine and glutamate microdialysate content were observed and indicated a learned compensatory response to counteract the acute effects of ethanol. These results demonstrate that changes in amygdala extracellular glutamate and taurine concentrations can be conditioned to ethanol-associated stimuli and are therefore probably implicated in the phenomenon of environmental-dependent tolerance to ethanol.
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Neurosciences & behavior
Pharmacy, pharmacology & toxicology
Author, co-author :
Quertemont, Etienne  ;  Université de Liège - ULiège > Département des sciences cognitives > Psychologie quantitative
de Neuville, Jessica;  Université Catholique de Louvain - UCL > Biologie du Comportement
De Witte, Philippe;  Université Catholique de Louvain - UCL > Biologie du Comportement
Language :
English
Title :
Changes in the amygdala amino acid microdialysate after conditioning with a cue associated with ethanol
Publication date :
1999
Event name :
7th Congress of the European Society for Biomedical Research on Alcoholism
Event organizer :
European Society for Biomedical Research on Alcoholism (ESBRA)
Event place :
Barcelona, Spain
Audience :
International
Journal title :
Alcohol and Alcoholism
ISSN :
0735-0414
eISSN :
1464-3502
Publisher :
Oxford University Press, Oxford, United Kingdom
Volume :
34
Pages :
441
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