Reference : Alcohol-non-preferring Sardinian rats exhibit a higher ethanol-induced taurine increase ...
Scientific congresses and symposiums : Paper published in a journal
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/40939
Alcohol-non-preferring Sardinian rats exhibit a higher ethanol-induced taurine increase compared to alcohol-preferring Sardinian rats: a microdialysis study
English
Quertemont, Etienne mailto [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
Lallemand, Frédéric [Université Catholique de Louvain - UCL > > Biologie du comportement > >]
Colombo, Giancarlo [University of Cagliari > > > >]
De Witte, Philippe [Université Catholique de Louvain - UCL > > Biologie du Comportement > >]
1999
Alcohol & Alcoholism
Oxford University Press
34
474
No
No
International
0735-0414
1464-3502
Oxford
United Kingdom
7th Congress of the European Society for Biomedical Research on Alcoholism
European Society for Biomedical Research on Alcoholism (ESBRA)
Barcelona
Spain
[en] Ethanol ; Taurine ; Microdialysis ; Sardininan rats ; Alcohol preference
[en] It is well known that ethanol injections induce increases in the extracellular taurine concentration from various rat brain regions. Furthermore, recent studies have shown that taurine supplementation modulates the ethanol reinforcing effects in a place conditioning experiment. However, it is unknown whether there is a relationship between this taurine increase and the ethanol drinking behaviors. In the present microdialysis experiments, we compared the effects of ethanol injections (1.0 and 2.0 g/kg) on the extracellular taurine concentration from the nucleus accumbens of either Sardinian alcohol-preferring or Sardinian alcohol-non-preferring rats which have been selectively bred for their differential ethanol preference. The results show that acute ethanol produces an immediate increase in the taurine microdialysate content from both rat lines. However, this increase in taurine microdialysate content was more potent in the alcohol-non-preferring rats. Since taurine has been postulated to be released by brain cells to modulate some of the adverse effects of ethanol, the higher increase in taurine microdialysate content in the alcohol-non-preferring rats is probably related to their higher vulnerability to ethanol aversive effects.
Centre de Neurosciences Cognitives et Comportementales
Researchers ; Professionals
http://hdl.handle.net/2268/40939

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Abstarct Barcelone2.pdfAuthor preprint5.74 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.