Reference : STEM CELLS IN THE ADULT RAT SPINAL CORD: PLASTICITY AFTER INJURY AND TREADMILL TRAINI...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/40798
STEM CELLS IN THE ADULT RAT SPINAL CORD: PLASTICITY AFTER INJURY AND TREADMILL TRAINING EXERCISE.
English
Foret, Ariane mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Quertainmont, Renaud [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Botman, O. [> > > >]
Bouhy, D. [> > > >]
Amabili, P. [> > > >]
Brook, G. [> > > >]
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Franzen, Rachelle mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Feb-2010
Journal of Neurochemistry
Blackwell Science
112
3
762-772
Yes (verified by ORBi)
International
0022-3042
1471-4159
Oxford
United Kingdom
[en] neural stem cells ; spinal cord injury ; epemdyma
[en] ABSTRACT Ependymal cells located around the central canal of the adult spinal cord are considered as a source of neural stem cells (NSCs) and represent an interesting pool of endogenous stem cells for repair strategies. Physical exercise is known to increase ependymal cell proliferation, while improving functional recovery. In this work, we further characterized those endogenous NSCs within the normal and injured adult rat spinal cord and investigated the effects of treadmill training using immunohistochemical and behavioural studies. In uninjured untrained rats, Sox-2, a NSC marker, was detected in all ependymal cells of the central canal, and also scattered throughout the parenchyma of the spinal cord. Within the lesion, Sox-2 expression increased transiently, while the number of nestin-positive ependymal cells increased with a concomitant enhancement of proliferation, as indicated by the mitotic markers Ki67 and BrdU. Exercise, which improved functional recovery and autonomous micturition, maintained nestin expression in both injured and uninjured spinal cords, with a positive correlation between locomotor recovery and the number of nestin-positive cells.
Giga-Neurosciences
communautés européennes
Researchers
http://hdl.handle.net/2268/40798
also: http://hdl.handle.net/2268/12922 ; http://hdl.handle.net/2268/80186
10.1111/j.1471-4159.2009.06500.x

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