Resolution Improvement by Use of Carboxymethyl-Beta-Cyclodextrin as Chiral Additive for the Enantiomeric Separation of Basic Drugs by Capillary Electrophoresis

Fillet, Marianne; Bechet, I.; Hubert, Philippe; Crommen, Jacques

doi:10.1016/S0731-7085(95)01756-9

Article (Scientific journals)

Resolution Improvement by Use of Carboxymethyl-Beta-Cyclodextrin as Chiral Additive for the Enantiomeric Separation of Basic Drugs by Capillary Electrophoresis

Fillet, Marianne; Bechet, I.; Hubert, Philippe et al.

1996 • In Journal of Pharmaceutical and Biomedical Analysis, 14 (8-10), p. 1107-14

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https://hdl.handle.net/2268/22542

DOI
10.1016/S0731-7085(95)01756-9

PubMed
8818022

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Abstract :

[en] Three beta-cyclodextrin derivatives--carboxymethyl-, dimethyl- and hydroxypropyl-beta-cyclodextrin--were tested as chiral selectors for the enantioseparation of seven basic drugs in free solution capillary electrophoresis, using buffers made of 100 mM phosphoric acid adjusted to pH 3.0 with triethanolamine in fused silica capillaries thermostatted at 15 degrees C. The best results with respect to chiral resolution were obtained with carboxymethyl-beta-cyclodextrin (CMCD): the enantiomers of all compounds examined were completely resolved with this beta-cyclodextrin derivative. The influence of the CMCD concentration on the migration times, the apparent electrophoretic mobility difference and the resolution of the drug enantiomers was investigated thoroughly. Particularly impressive resolution values, up to 23.7, were obtained for several compounds in these capillary electrophoretic systems, using CMCD in the 5-15 mM concentration range.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Bechet, I.

Hubert, Philippe ; Université de Liège - ULiège > Chimie analytique

Crommen, Jacques ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Language :

English

Title :

Resolution Improvement by Use of Carboxymethyl-Beta-Cyclodextrin as Chiral Additive for the Enantiomeric Separation of Basic Drugs by Capillary Electrophoresis

Publication date :

June 1996

Journal title :

Journal of Pharmaceutical and Biomedical Analysis

ISSN :

0731-7085

eISSN :

1873-264X

Publisher :

Elsevier, Amsterdam, Netherlands

Volume :

Issue :

8-10

Pages :

1107-14

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 May 2010

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