[en] Haplophyllum foliosum ; H. pedicellatum ; Rutaceae ; new quinoline alkaloid folipidine ; chemical transformations ; spectral data (UV, IR, mass, NMR, 2D(1)H-H-1 COSY, NOESY, H-1-C-13 HSQC, HMBC) ; antitumor activity
[en] The new quinoline alkaloid folipidine, the structure of which was established by chemical transformations and spectral data (UV, IR, mass, NMR) using APT 2D H-1-H-1 COSY, NOESY, and H-1-(13)CHSQC, HMBC, was isolated from two plants of the Haplophyllum mints. Folipidine is the first representative of a new type of quinoline alkaloids that contain a heteroaromatic skeleton of [3,4-b]conjugated pyrrole and quinoline fragments. The total alkaloids of these plants exhibit antitumor activity. Folipidine does not possess such activity.