ORBi: De Backer Benjamin - Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoïds in cannabis plant material

Reference : Innovative development and validation of an HPLC/DAD method for the qualitative and quan...


	Document type :	Scientific congresses and symposiums : Poster
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/2268/40563

Title :	Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoïds in cannabis plant material
Language :	English
Author, co-author :	De Backer, Benjamin [Université de Liège - ULg > Département de pharmacie > Chimie toxicologique >]
	Debrus, Benjamin [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
	Lebrun, Pierre [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
	Dubois, Nathalie [Université de Liège - ULg > > Toxicologie clinique >]
	Hubert, Philippe [Université de Liège - ULg > Département de pharmacie > Chimie analytique >]
	Charlier, Corinne [Université de Liège - ULg > Département de pharmacie > Chimie toxicologique >]
Publication date :	Aug-2009
Audience :	International
Event name :	47ème meeting de l'International Association of Forensic Toxicologists (TIAFT)
Event date :	23-27 août 2009
Event place (city) :	Genève
Event country :	Suisse
Keywords :	[en] HPLC ; cannabis sativa ; cannabinoids ; THC ; CBD ; CBG
Abstract :	[en] GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their neutral counterparts. Converely, HPLC permits the determination of the original composition of plant cannabinoids by direct analysis. Several HPLC methods have been described in the literature, but most of them failed to separate efficiently all the cannabinoids or were not validated according to general guidelines. By use of an innovative methodology for modelling chromatographic responses, a simple and accurate HPLC/DAD method was develop
Research units :	CIRM
Funders :	Belspo
Permalink :	http://hdl.handle.net/2268/40563
	also: http://hdl.handle.net/2268/35417

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