ORBi: Lemaire Christian - Fast Production of Highly Reactive No-Carrier-Added [18F]Fluoride for the Labeling of Radiopharmaceuticals

Reference : Fast Production of Highly Reactive No-Carrier-Added [18F]Fluoride for the Labeling of Ra...


	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/40483

Title :	Fast Production of Highly Reactive No-Carrier-Added [18F]Fluoride for the Labeling of Radiopharmaceuticals
Language :	English
Author, co-author :	Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Aerts, Joël [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Voccia, Samuel [> >]
	Libert, Lionel [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Mercier, Frédéric [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Goblet, David [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Plenevaux, Alain [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Luxen, André [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Publication date :	2010
Journal title :	Angewandte Chemie (International ed. in English)
Publisher :	Wiley-VCH Verlag Gmbh
Volume :	49
Pages :	1-5
Audience :	International
ISSN :	1433-7851
e-ISSN :	1521-3773
City :	Weinheim
Country :	Germany
Abstract :	[en] The 18F labeling of radiopharmaceuticals requires nearly anhydrous solutions of [18F]fluoride. Aqueous K2CO3 is generally used to elute [18F]fluoride from an anion-exchange resin. Replacing aqueous K2CO3 with strong organic bases, such as the phosphazene base P2Et enabled the recovery of highly reactive [18F]fluoride and avoided the azeotropic evaporation of water, which is very difficult on a microchip device.
Research units :	Centre de Recherches du Cyclotron - CRC
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/40483

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