Article (Scientific journals)
DNA methylation and cancer diagnosis: new methods and applications.
Dehan, Pierre; Kustermans, Gaëlle; Guénin, Samuel et al.
2009In Expert Review of Molecular Diagnostics, 9 (7), p. 651-7
Peer Reviewed verified by ORBi
 

Files


Full Text
Dehan et al 2009.pdf
Publisher postprint (191.91 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
DNA Methylation; Epigenesis, Genetic; Humans; Neoplasms/diagnosis/genetics; Tumor Markers, Biological
Abstract :
[en] Methylation of cytosines in cytosine-guanine (CpG) dinucleotides is one of the most important epigenetic alterations in animals. The presence of methylcytosine in the promoter of specific genes has profound consequences on local chromatin structure and on the regulation of gene expression. Changes in DNA methylation play a central role in carcinogenesis. Hypermethylation and consecutive transcriptional silencing of tumor-suppressor genes has been documented in numerous cancers. The identification of target genes silenced by this modification has a great impact on diagnosis, classification, definition of risk groups and prognosis of cancer patients. Here we outline genome-wide techniques aiming at the identification of relevant methylated promoters. Methods and applications allowing clinicians to monitor the methylation of target genes will be also reviewed.
Disciplines :
Oncology
Author, co-author :
Dehan, Pierre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Kustermans, Gaëlle ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Guénin, Samuel ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Horion, Julie ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Boniver, Jacques ;  Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Language :
English
Title :
DNA methylation and cancer diagnosis: new methods and applications.
Publication date :
2009
Journal title :
Expert Review of Molecular Diagnostics
ISSN :
1473-7159
eISSN :
1744-8352
Publisher :
Future Medicine Ltd
Volume :
9
Issue :
7
Pages :
651-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 February 2010

Statistics


Number of views
128 (21 by ULiège)
Number of downloads
2 (0 by ULiège)

Scopus citations®
 
78
Scopus citations®
without self-citations
77
OpenCitations
 
66

Bibliography


Similar publications



Contact ORBi