Reference : DNA methylation and cancer diagnosis: new methods and applications.
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/40473
DNA methylation and cancer diagnosis: new methods and applications.
English
Dehan, Pierre mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Kustermans, Gaëlle mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Guénin, Samuel [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Horion, Julie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Boniver, Jacques mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Delvenne, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
2009
Expert Review of Molecular Diagnostics
Future Medicine Ltd
9
7
651-7
Yes (verified by ORBi)
International
1473-7159
1744-8352
[en] DNA Methylation ; Epigenesis, Genetic ; Humans ; Neoplasms/diagnosis/genetics ; Tumor Markers, Biological
[en] Methylation of cytosines in cytosine-guanine (CpG) dinucleotides is one of the most important epigenetic alterations in animals. The presence of methylcytosine in the promoter of specific genes has profound consequences on local chromatin structure and on the regulation of gene expression. Changes in DNA methylation play a central role in carcinogenesis. Hypermethylation and consecutive transcriptional silencing of tumor-suppressor genes has been documented in numerous cancers. The identification of target genes silenced by this modification has a great impact on diagnosis, classification, definition of risk groups and prognosis of cancer patients. Here we outline genome-wide techniques aiming at the identification of relevant methylated promoters. Methods and applications allowing clinicians to monitor the methylation of target genes will be also reviewed.
http://hdl.handle.net/2268/40473
10.1586/erm.09.53

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