Article (Scientific journals)
Oral glucose tolerance tests in treated patients with schizophrenia. Data to support an adaptation of the proposed guidelines for monitoring of patients on second generation antipsychotics?
De Hert, Marc; Van Eyck, Dominique; Hanssens, Linda et al.
2006In European Psychiatry, 21 (4), p. 224-226
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Keywords :
schizophrenia; diabetes; metabolic syndrome; antipsychotics
Abstract :
[en] Objective. - A recent consensus conference has proposed guidelines for the monitoring for diabetes in patients with schizophrenia and also identifies the need of long-term prospective studies. Method. - A large scale prospective study on metabolic risks of antipsychotic medication is currently ongoing. At baseline, patients get a full laboratory screening, ECG and an oral glucose tolerance test (OGTT). Baseline data on 100 non-diabetic patients at study inclusion and stable on medication for at least 6 months are presented. Results. - Glucose abnormalities are found in 22% of patients at baseline, A monitoring protocol based only on fasting glucose would not have detected 63.6% of these patients with classifiable glucose abnormalities in our sample. Fasting insulin and measures for insulin resistance have a high predictive value for abnormalities late in the OGTT. Conclusion. - Already at baseline, metabolic problems are frequently present in patients with schizophrenia treated with antipsychotics. Adding assessment of fasting insulin in a monitoring protocol improves detection of glucose abnormalities late in an OGTT. (c) 2005 Elsevier SAS. All rights reserved.
Disciplines :
Endocrinology, metabolism & nutrition
Psychiatry
Author, co-author :
De Hert, Marc
Van Eyck, Dominique
Hanssens, Linda
Peuskens, Hendrik
Thys, Erik
Wampers, Martien
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Peuskens, Jozef
Language :
English
Title :
Oral glucose tolerance tests in treated patients with schizophrenia. Data to support an adaptation of the proposed guidelines for monitoring of patients on second generation antipsychotics?
Publication date :
June 2006
Journal title :
European Psychiatry
ISSN :
0924-9338
eISSN :
1778-3585
Publisher :
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris, France
Volume :
21
Issue :
4
Pages :
224-226
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
European Psychiatry 21 (2006) 224–226
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