Reference : Metoprolol v. clonidine in the prophylactic treatment of migraine.
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
http://hdl.handle.net/2268/40234
Metoprolol v. clonidine in the prophylactic treatment of migraine.
English
Louis, P. [ > > ]
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Hedman, C. [> > > >]
1985
Cephalalgia : An International Journal of Headache
Blackwell Science
5
3
159-65
International
0333-1024
1468-2982
Osney Mead Oxford
United Kingdom
[en] Adolescent ; Adult ; Child ; Child, Preschool ; Clinical Trials as Topic ; Clonidine/therapeutic use ; Double-Blind Method ; Drug Tolerance ; Female ; Humans ; Male ; Metoprolol/therapeutic use ; Migraine Disorders/complications/drug therapy ; Random Allocation
[en] In a double-blind, cross-over trial, the migraine prophylactic effect of the beta 1-adrenoceptor antagonist metoprolol was compared with that of clonidine. The dosage of metoprolol was 50 mg b.i.d. and of clonidine 50 micrograms b.i.d. Thirty-one patients were included; twenty-three completed the entire study. Six patients withdrew during clonidine treatment, one during metoprolol treatment and one during the wash-out period (placebo). Metoprolol had a significantly better migraine prophylactic effect than clonidine regarding such parameters as the attack frequency, the number of migraine days and the sum of intensity score. Compared to baseline (placebo), metoprolol decreased these parameters, while clonidine did not. Metoprolol, but not clonidine, also reduced the acute consumption of analgesics. No differences were found as regards side effects.
http://hdl.handle.net/2268/40234

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