Article (Scientific journals)
8-Chloro-6-(3-dimethylaminopropylamino)-11H-pyrido[2,3-b][1,4]benzodiazepine
Dupont, Léon; Eyrolles, Laurence; Evrard, Guy et al.
2002In Acta Crystallographica. Section E, Structure Reports Online, 58 (Part 1), p. 69-O71
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Abstract :
[en] The crystal structure determination of the title compound, C17H20ClN5, has been undertaken as part of studies on antipsychotic drugs. Its structure is compared with that of clozapine (C18H19ClN4), a well known atypical antipsychotic drug. The side chain is more flexible than in the N-methylpiperazine analogues, but its folding is influenced by an intramolecular N-H . . .N hydrogen bond. The distances between the N-distal atom, a possible pharmacophore, and the centres of the two aromatic rings are significantly shorter than in clozapine. The crystal packing involves one N-H . . .N intermolecular hydrogen bond. The title compound showed no affinity for the receptors tested.
Disciplines :
Physics
Author, co-author :
Dupont, Léon ;  Cristallographie
Eyrolles, Laurence
Evrard, Guy
Delarge, Jacques
Liégeois, Jean-François ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Language :
English
Title :
8-Chloro-6-(3-dimethylaminopropylamino)-11H-pyrido[2,3-b][1,4]benzodiazepine
Publication date :
January 2002
Journal title :
Acta Crystallographica. Section E, Structure Reports Online
ISSN :
1600-5368
Publisher :
Blackwell Munksgaard, Copenhagen, Denmark
Volume :
58
Issue :
Part 1
Pages :
O69-O71
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 January 2009

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