Reference : 8-Chloro-6-(3-dimethylaminopropylamino)-11H-pyrido[2,3-b][1,4]benzodiazepine
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Physics
http://hdl.handle.net/2268/4018
8-Chloro-6-(3-dimethylaminopropylamino)-11H-pyrido[2,3-b][1,4]benzodiazepine
English
Dupont, Léon mailto [> > Cristallographie >]
Eyrolles, Laurence [> > > >]
Evrard, Guy [ > > ]
Delarge, Jacques [> > > >]
Liégeois, Jean-François mailto [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique >]
Jan-2002
Acta Crystallographica Section E-Structure Reports Online
Blackwell Munksgaard
58
Part 1
O69-O71
Yes (verified by ORBi)
International
1600-5368
Copenhagen
[en] The crystal structure determination of the title compound, C17H20ClN5, has been undertaken as part of studies on antipsychotic drugs. Its structure is compared with that of clozapine (C18H19ClN4), a well known atypical antipsychotic drug. The side chain is more flexible than in the N-methylpiperazine analogues, but its folding is influenced by an intramolecular N-H . . .N hydrogen bond. The distances between the N-distal atom, a possible pharmacophore, and the centres of the two aromatic rings are significantly shorter than in clozapine. The crystal packing involves one N-H . . .N intermolecular hydrogen bond. The title compound showed no affinity for the receptors tested.
Researchers ; Professionals
http://hdl.handle.net/2268/4018
10.1107/S1600536801021286

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