Article (Scientific journals)
Long-term effects of JL 13, a potential atypical antipsychotic, on rat dopamine and serotonin receptor subtypes
Moran-Gates, Taylor; Massari, Carla; Graulich, Amaury et al.
2006In Journal of Neuroscience Research, 84 (3), p. 675-682
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Keywords :
autoradiography; antipsychotic drugs; caudate-putamen; dopamine receptors; frontal cortex; JL 13; serotonin receptors
Abstract :
[en] Changes in dopamine (DA) D-1, D-2, D-3, and D-4 receptors and serotonin 5-HT1A and 5-HT2A receptors in rat forebrain regions were autoradiographically quantified after continuous infusion of JL 13 [(5-(4-methylpiperazin-1-yl)8-chloro-pyrido[2,3-b][1,5]benzoxazepine fumarate] for 28 days with osmotic minipumps and compared with the effects of other typical (fluphenazine) and atypical (clozapine, olanzapine, and risperidone) antipsychotic drugs from previous studies. Similar to other typical and atypical antipsychotics, JL 13 increased labeling of D2 receptors in medial prefrontal cortex (MPC) and hippocampus (HIP) and D-4 receptors in nucleus accumbens (NAc), caudate-putamen (CPu), and HIP In addition, JL 13 increased 5-HT1A and decreased 5-HT2A receptors in MPC and dorsolateral frontal cortex (DFC), an effect shared by atypical antipsychotics, and may contribute to their psychopharmacological properties. Clozapine and JL 13, but not other antipsychotics, spared D2 receptors in CPu, which may reflect their ability to induce minimal extrapyramidal side effects. In addition, JL 13 but not other typical and atypical antipsychotic drugs increased abundance of D, receptors in CPu and NAc. JL 13 as well as other antipsychotic agents did not alter levels of forebrain D3 receptors. An atypical-like profile of JL 13 on DA and 5-HT receptor subtypes should encourage further development of this compound as a novel atypical anti psychotic drug. (c) 2006Wiley-Liss, Inc.
Disciplines :
Neurosciences & behavior
Author, co-author :
Moran-Gates, Taylor;  Massachusetts General Hospital > McLean Division > Mailman Research Center
Massari, Carla;  Massachusetts General Hospital > McLean Division > Mailman Research Center
Graulich, Amaury ;  Université de Liège - ULiège > Chimie pharmaceutique
Liégeois, Jean-François ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Tarazi, Frank I.;  Harvard Medical School (Boston) > Department of Psychiatry and Neuroscience Program
Language :
English
Title :
Long-term effects of JL 13, a potential atypical antipsychotic, on rat dopamine and serotonin receptor subtypes
Publication date :
15 August 2006
Journal title :
Journal of Neuroscience Research
ISSN :
0360-4012
eISSN :
1097-4547
Publisher :
Wiley Liss, Inc., Hoboken, United States - New Jersey
Volume :
84
Issue :
3
Pages :
675-682
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 January 2009

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