Reference : Modélisation moléculaire de l'usambarensine, de la tubulosine et de l'émétine, alcalo...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Physics
Human health sciences : Pharmacy, pharmacology & toxicology
Modélisation moléculaire de l'usambarensine, de la tubulosine et de l'émétine, alcaloïdes cytotoxiques et antiamibiens
[en] Molecular Modelling of Usambarensine, Tubulosine and Emetine, Cytotoxic Amebicide Alkaloids
Quetin-Leclercq, J. [> > > >]
Dupont, Léon mailto [> > Cristallographie >]
Wright, C. W. [> > > >]
Phillipson, J. D. [> > > >]
Warhurst, D. C. [> > > >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Journal de Pharmacie de Belgique
2, Mar-Apr
Yes (verified by ORBi)
[en] usambarensine ; tubulosine ; emetine ; conformational analysis
[en] The analyses of the different possible conformations of usambarensine, tubulosine and emetine, which possess interesting cytotoxic and amoebicide properties showed us that they cannot take the planar conformation proposed to explain the activity of this type of molecules on protein synthesis. Nevertheless, a common (non planar) conformation exists where the angles between the two plans containing the aromatic rings are nearly the same for the three compounds. This fact could confirm the hypothesis of a common receptor which would be slightly different in amoebae because of its higher sensitivity to usambarensine.

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J.Pharm. Belg. 1991, 46, 85-92.pdfPublisher postprint1.26 MBRequest copy

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