Article (Scientific journals)
Expression of the Mr 67,000 laminin receptor is an adverse prognostic indicator in human thyroid cancer: an immunohistochemical study.
Basolo, F.; Pollina, L.; Pacini, F. et al.
1996In Clinical Cancer Research, 2 (10), p. 1777-80
Peer Reviewed verified by ORBi
 

Files


Full Text
(47) BASOLO F CLIN CANCER RES 1996.pdf
Publisher postprint (1.97 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Adult; Aged; Female; Humans; Immunohistochemistry; Male; Middle Aged; Predictive Value of Tests; Prognosis; Receptors, Laminin/biosynthesis; Survival Analysis; Thyroid Neoplasms/metabolism/pathology
Abstract :
[en] Increased expression of the Mr 67,000 laminin receptor (LR) is a consistent event which appears as cancer cells acquire an invasive and metastatic phenotype. The Mr 67,000 LR is one of the many laminin-binding proteins able to interact with the major glycoprotein of basement membranes, laminin. The recent development of a specific monoclonal antibody directed against the Mr 67,000 LR MLuC5 has allowed us to study large retrospective groups of human cancers with the aim of correlating the Mr 67,000 LR expression to the clinical, pathological, and survival data of the patients. A significant correlation has already been established between the increased expression of Mr 67,000 LR and survival of patients with breast, colon, ovary, lung, and endometrial cancers. In this study, we investigated the possibility that the detection of Mr 67,000 LR in thyroid human cancers could also be of prognostic value. We analyzed the expression of Mr 67,000 LR with immunohistochemistry using MLuC5 antibodies in paraffin sections of 40 benign and 170 malignant thyroid human tumors. We found that Mr 67,000 LR was not usually detectable in normal thyroid tissues adjacent to the lesion. Only 3 of the 40 thyroid adenomas examined (7.5%) presented cells positive for Mr 67,000 LR. For the malignant thyroid tumors examined, we found that 22.3% of papillary thyroid carcinomas, 38% of follicular thyroid carcinomas, 40% of poorly differentiated carcinomas, 25% of medullary carcinomas, and 58.3% of anaplastic carcinomas expressed a high level of Mr 67,000 LR. Although no correlation between the Mr 67,000 LR expression and survival was found in patients with follicular thyroid carcinomas, papillary thyroid carcinomas, anaplastic carcinomas, and medullary carcinomas, there was a significant correlation in primary thyroid cancers. Our data represent the first extensive study of the Mr 67,000 LR expression in human thyroid cancers and strongly suggest that its detection could be of prognostic value in the investigation of primary thyroid cancers.
Disciplines :
Oncology
Biochemistry, biophysics & molecular biology
Author, co-author :
Basolo, F.
Pollina, L.
Pacini, F.
Fontanini, G.
Menard, S.
Castronovo, Vincenzo ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire - GIGA-R : Labo de recherche sur les métastases
Bevilacqua, G.
Language :
English
Title :
Expression of the Mr 67,000 laminin receptor is an adverse prognostic indicator in human thyroid cancer: an immunohistochemical study.
Publication date :
1996
Journal title :
Clinical Cancer Research
ISSN :
1078-0432
eISSN :
1557-3265
Publisher :
American Association for Cancer Research, Inc. (AACR), Birmingham, United States - Alabama
Volume :
2
Issue :
10
Pages :
1777-80
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 May 2010

Statistics


Number of views
27 (1 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
25
Scopus citations®
without self-citations
20

Bibliography


Similar publications



Contact ORBi