ORBi: Viacava P. - The spectrum of 67-kD laminin receptor expression in breast carcinoma progression.

Reference : The spectrum of 67-kD laminin receptor expression in breast carcinoma progression.


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Oncology Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/39593

Title :	The spectrum of 67-kD laminin receptor expression in breast carcinoma progression.
Language :	English
Author, co-author :	Viacava, P. [> > > >]
	Naccarato, A. G. [> > > >]
	Collecchi, P. [> > > >]
	Menard, S. [> > > >]
	Castronovo, Vincenzo [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire - GIGA-R : Labo de recherche sur les métastases >]
	Bevilacqua, G. [> > > >]
Publication date :	1997
Journal title :	Journal of Pathology (The)
Publisher :	John Wiley & Sons, Inc
Volume :	182
Issue/season :	1
Pages :	36-44
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0022-3417
City :	Chichester
Country :	United Kingdom
Keywords :	[en] Breast/metabolism/pathology ; Breast Neoplasms/metabolism/pathology ; Carcinoma in Situ/metabolism ; Carcinoma, Lobular/metabolism ; Disease Progression ; Female ; Humans ; Hyperplasia/metabolism ; Immunoenzyme Techniques ; Neoplasm Invasiveness ; Precancerous Conditions/metabolism ; Receptors, Laminin/metabolism
Abstract :	[en] Laminin is a glycoprotein of the basement membrane (BM), involved in a variety of normal and pathological cellular events including tumour invasion and metastasis. Cells bind laminin through different types of receptor. The 67-kD laminin receptor (67LR) is a cell-surface protein which binds laminin with high affinity. 67LR expression has been shown to increase in neoplastic cells, compared with normal tissues, and 67LR seems to play an important role during the first steps of neoplastic progression. In this study, 67LR expression was analysed during the morphological phases of breast cancer progression from normal tissue to invasive carcinoma. A total of 506 formalin-fixed, paraffin-embedded normal breast structures and lesions were stained by immunohistochemistry usign the MLuC5 monoclonal antibody, which is specific for 67LR. The results show that in normal breast and in any kind of breast lesion, myoepithelial and endothelial cells express 67LR. While 67LR is not seen in the epithelium of normal breast, cysts, adenosis, and benign tumours, it is expressed in the epithelial cells of several hyperplasias and carcinomas in situ, both ductal and lobular, as well as in all invasive carcinomas. The 67LR-positive cell subpopulation expands from hyperplastic lesions to invasive carcinoma, suggesting that 67LR could be related to the induction and progression of breast cancer.
Permalink :	http://hdl.handle.net/2268/39593
DOI :	10.1002/(SICI)1096-9896(199705)182:1<36::AID-PATH802>3.0.CO;2-W

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