Reference : Effects of Alpha-Hederin, a Saponin Extracted from Hedera Helix, on Cells Cultured in...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/39249
Effects of Alpha-Hederin, a Saponin Extracted from Hedera Helix, on Cells Cultured in Vitro
English
Danloy, S. [> > > >]
Quetin-Leclercq, J. [> > > >]
Coucke, P. [> > > >]
Gillet, Marie-Claire mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques >]
Elias, R. [> > > >]
Balansard, G. [> > > >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Bassleer, Roger [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
Feb-1994
Planta Medica
60
1
45-9
Yes (verified by ORBi)
International
0032-0943
[en] Hedera helix ; triterpenoid saponin ; alpha-hederin ; cytotoxicity ; B16 melanoma ; 3T3 fibroblasts
[en] In this work, we have analysed the effects of alpha-hederin, a monodesmosidic triterpenoid saponin isolated from Hedera helix, on mouse B16 melanoma cells and non-cancer mouse 3T3 fibroblasts cultured in vitro. Our results indicate that, in a serum-free medium, alpha-hederin is cytotoxic and inhibits proliferation in both cell lines at rather low concentrations (< 5 micrograms/ml) after only 8 hours of treatment. Its cytotoxicity decreases in the presence of serum in which BSA seems to be able to bind the saponin. alpha-Hederin also induces vacuolization of the cytoplasm and membrane alterations leading to cell death.
http://hdl.handle.net/2268/39249

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Planta Med. 60 (1994) pp 45_49.pdfPublisher postprint404.82 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.