Reference : Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with Paclitaxel
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/3911
Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with Paclitaxel
English
Danhier, Fabienne [Université catholique de Louvain (UCL), Bruxelles > > Unité de Pharmacie Galénique > >]
Vroman, Benoît [Université catholique de Louvain (UCL), Bruxelles > > Unité de Pharmacie Galénique > >]
Lecouturier, Nathalie [Université catholique de Louvain (UCL), Bruxelles > > Unité de Pharmacie Galénique > >]
Crokart, Nathalie [Université catholique de Louvain (UCL), Bruxelles > > Unité de Pharmacie Galénique > >]
Pourcelle, Vincent [Université catholique de Louvain (UCL) > > Unité de Chimie Organique et Médicinale > >]
Freichels, Hélène [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Marchand-Brynaert, Jacqueline [Université catholique de Louvain (UCL) > > Unité de Chimie Organique et Médicinale > >]
Feron, Olivier [Université catholique de Louvain (UCL), Bruxelles > > Laboratoire de Pharmacologie et de Thérapeutique > >]
Préat, Véronique [Université catholique de Louvain (UCL), Bruxelles > > Unité de Pharmacie Galénique > >]
3-Dec-2009
Journal of Controlled Release
Elsevier Science
140
2
166-173
Yes (verified by ORBi)
International
0168-3659
1873-4995
Amsterdam
The Netherlands
[en] biomaterial ; nanomedecine ; organic nanoparticle
[en] Paclitaxel (PTX)-loaded PEGylated PLGA-based nanoparticles (NP) have been previously described as more effective in vitro and in vivo than Taxol®. The aim of this study was to test the hypothesis that our PEGylated PLGA-based nanoparticles grafted with the RGD peptide or RGD-peptidomimetic (RGDp) would target the tumor endothelium and would further enhance the anti-tumor efficacy of PTX. The ligands were grafted on the PEG chain of PCL-b-PEG included in the nanoparticles. We observed in vitro that RGD-grafted nanoparticles were more associated to Human Umbilical Vein Endothelial cells (HUVEC) by binding to αvβ3 integrin than non-targeted nanoparticles. Doxorubicin was also used to confirm the findings observed for PTX. In vivo, we demonstrated the targeting of RGD and RGDp-grafted nanoparticles to tumor vessels as well as the effective retardation of TLT tumor growth and prolonged survival times of mice treated by PTX-loaded RGD-nanoparticles when compared to non-targeted nanoparticles. Hence, the targeting of anti-cancer drug to tumor endothelium by RGD-labeled NP is a promising approach.
Center for Education and Research on Macromolecules (CERM)
the FRSM ; the Fonds J. Maisin ; the “Région Wallonne” in the frame of the VACCINOR project
Researchers
http://hdl.handle.net/2268/3911
10.1016/j.jconrel.2009.08.011
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T3D-4X1YC9S-2-H&_cdi=4944&_user=532038&_orig=browse&_coverDate=12%2F03%2F2009&_sk=998599997&view=c&wchp=dGLbVlb-zSkzk&md5=b4184b42a105ebe137584f1690be09a6&ie=/sdarticle.pdf
http://www.elsevier.com/wps/find/journaldescription.cws_home/502690/description#description
The authors acknowledge Journal of Controlled Release (Elsevier) for allowing them to archive this paper.

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