Reference : Expression of the growth hormone variant gene in human placenta
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/23695
Expression of the growth hormone variant gene in human placenta
English
Frankenne, Francis [> >]
Rentier-Delrue, Françoise mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire - GIGA-R : Coordination scientifique >]
Scippo, Marie-Louise mailto [Université de Liège - ULg > Département de sciences des denrées alimentaires > CART, Analyse des denrées alimentaires > >]
Martial, Joseph mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Hennen, Georges [Université de Liège - ULg > > Endocrinologie clinique >]
1987
Journal of Clinical Endocrinology and Metabolism
Endocrine Society
64
3
635-637
Yes (verified by ORBi)
International
0021-972X
Chevy Chase
MD
[en] GROWTH HORMONE ; PLACENTA ; GH gene
[en] Besides the hGH-N gene, which codes for the pituitary 22 and 20K GH variants, the human genome contains a second GH gene, namely the GH-V, which has been thought to be silent. We recently discovered a placental variant of human growth hormone (hPGH), which appears in maternal serum at mid-pregnancy and which rises in concentration thereafter to term. As hPGH and GH-V proteins display very similar characteristics, including a high affinity for hepatic GH receptors, they could be identical. To verify this hypothesis, we sought hGH-V mRNA in placenta. Hybridization experiments were performed between dot-blotted mRNA originating either from placenta or from one pituitary hGH secreting adenoma and synthetic polynucleotide probes corresponding to specific portions of the hGH-V or hGH-N gene sequences. The results indicate that the V gene is indeed expressed in the placenta and, at a very low level, in the pituitary adenoma. Therefore hPGH is most likely the expression product of the hGH-V gene.
http://hdl.handle.net/2268/23695
also: http://hdl.handle.net/2268/38974
10.1210/jcem-64-3-635
http://jcem.endojournals.org/cgi/content/abstract/64/3/635

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