|Reference : Cutaneous and basophilic sensitivity to substance P and gastrin in non-atopic versus ato...|
|Scientific journals : Article|
|Human health sciences : Cardiovascular & respiratory systems|
|Cutaneous and basophilic sensitivity to substance P and gastrin in non-atopic versus atopic subjects.|
|Louis, Renaud [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]|
|Radermecker, Maurice [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]|
|[en] Adult ; Basophils/drug effects/immunology ; Concanavalin A/administration & dosage/pharmacology ; Gastrins/administration & dosage/pharmacology ; Histamine/administration & dosage/pharmacology ; Histamine Release ; Humans ; Hypersensitivity, Immediate/immunology ; Immunoglobulin E/immunology ; Injections, Intradermal ; Middle Aged ; Skin/drug effects/immunology ; Substance P/administration & dosage/pharmacology ; Time Factors|
|[en] We compared the cutaneous reaction to intradermal injection of substance P, gastrin and histamine in asymptomatic atopic subjects with a history of hay fever and/or asthma versus non-atopic healthy volunteers. We also studied in these two groups the basophilic histamine release induced by substance P and gastrin with that obtained with anti-human IgE and Con A. Intradermal injection of substance P (3-300 pM) and gastrin (3-30 pM) caused a wheal and flare reaction which was comparable in both groups of subjects. Substance P 10(-4)M caused a mean basophilic histamine release of about 15% in atopic and non-atopic subjects. Gastrin was not effective in this model. Anti-IgE and Con A-induced histamine release was significantly higher in atopic than in non-atopic volunteers.|
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