Article (Scientific journals)
Determination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample
Dehouck, Pieter; Vander Heyden, Yvan; Smeyers-Verbeke, Johanna et al.
2003In Analytica Chimica Acta, 481, p. 261-272
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Keywords :
Uncertainty; Collaborative study; Reproducibility; Phenoxymethylpenicillin
Abstract :
[en] The correct interpretation of a measurement result requires knowledge about its uncertainty. Depending on the conditions under which the analyst is operating, different operational definitions of uncertainty have been proposed. They include: within-laboratory uncertainty, reproducibility uncertainty, bias-included uncertainty and absolute uncertainty. Here we consider the evaluation of the reproducibility uncertainty derived from the results obtained in an inter-laboratory experiment. Nine laboratories participated in an inter-laboratory study for the analysis of phenoxymethylpenicillin. The analyses consisted of a Karl–Fischer water determination, an acid–base titration to assay phenoxymethylpenicillin and a liquid chromatography (LC) method to determine 4-hydroxyphenoxymethylpenicillin and other impurities. The experimental set-up allowed to obtain for each determination s2 r and s2L as estimates of the repeatability variance (σ2r ) and the between-laboratory variance (σ2L), respectively. The reproducibility uncertainties for the different assays were then derived from these estimates.
Disciplines :
Chemistry
Author, co-author :
Dehouck, Pieter;  Vrije Universiteit Brussel - VUB
Vander Heyden, Yvan;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Smeyers-Verbeke, Johanna;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Massart, D. L.;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Crommen, Jacques 
Hubert, Philippe  
Marini Djang'Eing'A, Roland 
Smeets, O.S.N.M.
Decristoforo, G.
Van de Wauw, W.
De Beer, Jacques
Quaglia, M. G.
Stella, C.
Veuthey, Jean-Luc
Estevenon, O.
Van Schepdael, Ann
Roets, E.
Hoogmartens, Jos
More authors (8 more) Less
Language :
English
Title :
Determination of uncertainty in analytical measurements from collaborative study results on the analysis of a phenoxymethylpenicillin sample
Publication date :
17 January 2003
Journal title :
Analytica Chimica Acta
ISSN :
0003-2670
eISSN :
1873-4324
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
481
Pages :
261-272
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Research Contract No. NM/01/25
Funders :
Belgian Government (The Prime Ministers Service—Federal Office for Scientific and Cultural Affairs).
Available on ORBi :
since 22 May 2010

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