ORBi: Gabelica Valérie - Infrared Signature of DNA G-Quadruplexes in the Gas Phase

Reference : Infrared Signature of DNA G-Quadruplexes in the Gas Phase


	Document type :	Scientific journals : Short communication
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/385

Title :	Infrared Signature of DNA G-Quadruplexes in the Gas Phase
Language :	English
Author, co-author :	Gabelica, Valérie [Université de Liège - ULg > > Chimie physique, spectrométrie de masse >]
	Rosu, Frédéric [Université de Liège - ULg > > Chimie physique, spectrométrie de masse >]
	De Pauw, Edwin [Université de Liège - ULg > > Chimie physique, spectrométrie de masse >]
	Lemaire, Joël [UniVersité Paris Sud, F-91405 Orsay, France > > Laboratoire de Chimie Physiques - CLIO du CNRS > >]
	Gillet, Jean-Christophe [Univ. Paris 13 > > Laboratoire de Physique des Lasers du CNRS > >]
	Poully, Jean-Christophe [Univ. Paris 13 > > Laboratoire de Physique des Lasers du CNRS > >]
	Lecomte, Frédéric [Univ. Paris 13 > > Laboratoire de Physique des Lasers du CNRS > >]
	Grégoire, Gilles [Univ. Paris 13 > > Laboratoire de Physique des Lasers du CNRS > >]
	Schermann, Jean-Pierre [Univ. Paris 13 > > Laboratoire de Physique des Lasers du CNRS > >]
	Desfrançois, Charles [Univ. Paris 13 > > Laboratoire de Physique des Lasers du CNRS > >]
Publication date :	2008
Journal title :	Journal of the American Chemical Society
Publisher :	American Chemical Society
Volume :	130
Issue/season :	6
Pages :	1810-1
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0002-7863
e-ISSN :	1520-5126
City :	Washington
Country :	DC
Keywords :	[en] infrared ; spectroscopy ; mass spectrometry ; G-quadruplex ; structure ; conformation ; DNA
Abstract :	[en] DNA oligonucleotide ions forming G-quadruplex structures were studied in the gas phase using IRMPD spectroscopy. Data interpretation on these large biomolecule ions was made using carefully chosen control experiments. The major finding is a fingerprint of hydrogen bonding in the gas phase in the guanine C6=O6 stretching mode, that allows probing the conservation of G-quartets in the gas phase. The experiments demonstrate the conservation of G-quadruplex hydrogen bonds in the human telomeric sequence d(TTAGGG)4.
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/385
DOI :	10.1021/ja077321w

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