[en] infrared ; spectroscopy ; mass spectrometry ; G-quadruplex ; structure ; conformation ; DNA
[en] DNA oligonucleotide ions forming G-quadruplex structures were studied in the gas phase using IRMPD spectroscopy. Data interpretation on these large biomolecule ions was made using carefully chosen control experiments. The major finding is a fingerprint of hydrogen bonding in the gas phase in the guanine C6=O6 stretching mode, that allows probing the conservation of G-quartets in the gas phase. The experiments demonstrate the conservation of G-quadruplex hydrogen bonds in the human telomeric sequence d(TTAGGG)4.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS