Letter to the editor (Scientific journals)
Sodium-Lithium countertransport in red cells
Krzesinski, Jean-Marie; Rorive, Georges
1983In New England Journal of Medicine, 309 (16), p. 987-988
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Keywords :
sodium-lithium countertransport; red cells; hemodialysis; intracellular sodium concentration; intracellular potassium concentration; ouabain-sensitive Na efflux
Abstract :
[en] To the Editor : Woods et al. provide evidence for a decrease in the rate of sodium-lithium countertransport in red cells after hemodialysis, and suggest that this effect is related to the removal of a plasma factor. They did not observe a difference in ouabain-dependent sodium efflux during hemodialysis, but this conclusion is based on data in only two patients. This latter observation disagrees with previous date, which demonstrated a decrease in the sodium-potassium pump activity in patients with chronic renal failure. We have studied the sodium exchange in red cells of 11 patients receiving hemodialysis. These date suggest that the modifications in the rate of ouabain-sensitive sodium efflux observed after hemodialysis may be related to a volume-dependent plasma factor and not only to a decrease in th concentration of a dialyzable factor; this factor may be similar to the "natriuretic digoxin-like factor" postulated by de Wardener and MacGregor as playing a part in primary hypertension. It is also possible that the effect observed by Woods et al. on sodium-lithium countertransport is linked to improvement of the sodium-pump activity.
Disciplines :
Urology & nephrology
Author, co-author :
Krzesinski, Jean-Marie ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Rorive, Georges ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Language :
English
Title :
Sodium-Lithium countertransport in red cells
Publication date :
20 October 1983
Journal title :
New England Journal of Medicine
ISSN :
0028-4793
eISSN :
1533-4406
Publisher :
Massachusetts Medical Society, Waltham, United States - Massachusetts
Volume :
309
Issue :
16
Pages :
987-988
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 May 2010

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